Accumulation of soluble inflammatory mediators between blood donation and pre-storage leucocyte depletion
Accumulation of soluble inflammatory mediators between blood donation and pre-storage leucocyte depletion
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DOI：
10.1111/j.1423-0410.2008.01132.x
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发表时间：
2009-01-01
期刊：
影响因子：
2.7
通讯作者：
Boenig, H.
中科院分区：
文献类型：
--
作者：
Chudziak, D.;Sireis, W.;Boenig, H.
白细胞衍生的细胞因子在储存的全血中积累。储存前白细胞去除降低了细胞因子水平，从而降低了发热性非溶血性输血反应。由于白细胞过滤和成分分离可以在献血后24小时内进行，我们假设在这段时间内，炎症细胞因子可能会积累。在献血后4、10和20小时收集系列血浆样本并测量细胞因子浓度。观察期间白细胞介素8增加>20倍，可溶性CD40配体>6倍，还观察到其他几种介质的变化不太明显。献血后10小时内白细胞减少将降低热原介质的浓度。
Leucocyte-derived cytokines accumulate in stored whole blood. Pre-storage leucocyte depletion has reduced cytokine levels and, consequently, febrile non-haemolytic transfusion reactions. As leucocyte filtration and component separation can be performed until 24 h after donation, we hypothesized that within this time, inflammatory cytokines might accumulate.Serial plasma samples were collected 4, 10 and 20 h after donation and cytokine concentrations were measured.Interleukin-8 increased > 20-fold and soluble CD40 ligand > sixfold during the observation time, less pronounced changes for several other mediators were also observed.Leucocyte depletion within 10 h of blood donation will reduce the concentrations of pyrogenic mediators.