CONVENTIONAL AND UVEO-SCLERAL DRAINAGE OF AQUEOUS HUMOUR IN CYNOMOLGUS MONKEY (MACACA IRUS) AT NORMAL AND HIGH INTRAOCULAR PRESSURES
CONVENTIONAL AND UVEO-SCLERAL DRAINAGE OF AQUEOUS HUMOUR IN CYNOMOLGUS MONKEY (MACACA IRUS) AT NORMAL AND HIGH INTRAOCULAR PRESSURES
复制标题
DOI：
10.1016/s0014-4835(66)80019-2
复制
发表时间：
1966-01-01
影响因子：
3.4
通讯作者：
BILL, A
中科院分区：
文献类型：
--
作者：
BILL, A
[131 I]白蛋白和[125 I]- [γ] -球蛋白用于标记幼龄食蟹猴的房水总流量。在活体动物中，在约11 mmHg的正常眼内压下，房水的净形成为1。24 [±] 0.13[mu]l/min。通过葡萄膜-巩膜途径的引流率为0。44 [加或减] 0。06 [mu]l/min，通过常规途径为0. 80 [±] 0.11 [mu] l/min。在通过额外流入将眼内压人工升高至22 mmHg时，通过葡萄膜-巩膜途径从前房流出为0。63 [正负] 0. 08 [mu]l/min，通过传统途径为4.18 [±] 0.12 [mu]l/min。这表明，在所研究的压力区域，眼内压的变化产生几乎相同的葡萄膜和脉络膜上组织压力的变化，这解释了为什么通过葡萄膜巩膜途径的流出在所研究的不同压力下是如此相似。死亡后，通过约5 [mu]l/min的流入将眼内压人工升高至14 mmHg，通过葡萄膜-巩膜途径从前房流出的平均量为1。25 [±] 0.17 [mu]l/min。
[131I] Albumin and [ 125I]- [gamma] -globulin were used to mark the bulk flow of aqueous humor in young cynomolgus monkeys. In living animals, at a normal intraocular pressure of about 11 mmHg, the net formation of aqueous humor was 1. 24 [plus or minus] 0.13[mu]l/min. The rate of drainage by way of uveo-scleral routes was 0. 44 [plus or minus] 0. 06 [mu]l/min and by way of conventional routes was 0. 80 [plus or minus] 0.11 [mu] l/min. At an intraocular pressure artificially raised to 22 mmHg by an extra inflow, the outflow from the anterior chamber by way of uveo-scleral routes was 0. 63 [plus or minus] 0. 08 [mu]l/min and by way of conventional routes was 4.18 [plus or minus] 0.12 [mu]l/min. It is suggested that, in the pressure region investigated, a change in intraocular pressure produces almost the same change in tissue pressure in the uvea and in the suprachoroid and that this explains why the outflow by way of uveo-scleral routes was so alike at the different pressures investigated. After death, at an intraocular pressure artificially raised to 14 mmHg by an inflow of about 5 [mu]l/min, the mean outflow from the anterior chamber by way of uveo-scleral routes was 1. 25 [plus or minus] 0.17 [mu]l/min.