Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis
Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis
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DOI：
10.1016/j.ebiom.2018.02.017
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发表时间：
2018-03-01
期刊：
影响因子：
11.1
通讯作者：
Stamenkovic, Ivan
中科院分区：
文献类型：
--
作者：
Fregni, Giulia;Quinodoz, Mathieu;Stamenkovic, Ivan
转移是一个多步骤的过程，其中癌细胞与其微环境之间的直接串扰起着关键作用。在这里，我们评估了配对的肿瘤相关和正常肺组织间充质干细胞（MSC）对从同一患者分离的原代人肺癌细胞的生长和扩散的影响。我们表明，肿瘤微环境调节MSC基因表达，并确定了一个四基因MSC签名，在功能上涉及促进转移。我们还证明，肿瘤相关的骨髓间充质干细胞诱导与原发性肺癌细胞中的侵袭性表型相关的基因的表达，并选择性地促进其传播，而不是局部生长。我们的观察提供了对间质促进肺癌转移的机制的深入了解。(C)2018由Elsevier B. V.发布这是CC BY-NC-ND许可下的开放获取文章。
Metastasis is a multi-step process in which direct crosstalk between cancer cells and their microenvironment plays a key role. Here, we assessed the effect of paired tumor-associated and normal lung tissue mesenchymal stem cells (MSCs) on the growth and dissemination of primary human lung carcinoma cells isolated from the same patients. We show that the tumor microenvironment modulates MSC gene expression and identify a four-gene MSC signature that is functionally implicated in promoting metastasis. We also demonstrate that tumor-associated MSCs induce the expression of genes associated with an aggressive phenotype in primary lung cancer cells and selectively promote their dissemination rather than local growth. Our observations provide insight into mechanisms by which the stroma promotes lung cancer metastasis. (C) 2018 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.