Celiac disease.
Celiac disease.
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DOI：
10.1186/1750-1172-1-3
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发表时间：
2006-03-01
影响因子：
3.7
通讯作者：
Caspary WF
中科院分区：
文献类型：
--
作者：
Holtmeier W;Caspary WF
乳糜泻是一种由面筋不耐受引起的慢性肠道疾病。它的特点是免疫介导的肠病，与消化不良和大多数营养物质和维生素的吸收不良有关。在易感人群中，摄入含面筋的食物，如小麦和黑麦，会导致空肠粘膜扁平，淋巴细胞渗入。主要症状有：胃痛、放气、腹胀、腹泻、体重减轻、贫血、浮肿、骨骼或关节疼痛。临床上常见的乳糜泻患病率从芬兰的1：270到北美的1：5000不等。由于乳糜泻可以是无症状的，所以大多数受试者没有被诊断出来，或者他们可能出现不典型的症状。此外，在没有任何胃肠道症状的情况下，可能会出现严重的小肠炎症。由于乳糜泻会导致未经治疗的儿童生长发育迟缓，以及不育或神经症状等非典型症状，因此应及早诊断。诊断需要内窥镜检查和空肠活检。此外，组织转谷氨酰胺酶抗体对确认诊断很重要，因为还有其他疾病可以模仿乳糜泻。乳糜泻的确切原因尚不清楚，但被认为主要是免疫调节的(组织转谷氨酰胺酶自身抗原)；通常这种疾病是遗传的。治疗包括终生停用膳食面筋，这会导致显著的临床和组织学改善。然而，组织学的完全正常化可能需要数年时间。
Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. The main symptoms are: stomach pain, gas, and bloating, diarrhea, weight loss, anemia, edema, bone or joint pain. Prevalence for clinically overt celiac disease varies from 1:270 in Finland to 1:5000 in North America. Since celiac disease can be asymptomatic, most subjects are not diagnosed or they can present with atypical symptoms. Furthermore, severe inflammation of the small bowel can be present without any gastrointestinal symptoms. The diagnosis should be made early since celiac disease causes growth retardation in untreated children and atypical symptoms like infertility or neurological symptoms. Diagnosis requires endoscopy with jejunal biopsy. In addition, tissue-transglutaminase antibodies are important to confirm the diagnosis since there are other diseases which can mimic celiac disease. The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen); often the disease is inherited. Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years.
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影响因子：
15.3
作者：
Arentz-Hansen, H;Korner, R;Molberg, O;Quarsten, H;Vader, W;Kooy, Y M;Lundin, K E;Koning, F;Roepstorff, P;Sollid, L M;McAdam, S N
通讯作者：
McAdam, S N
DOI：
10.1097/00042737-200501000-00017
发表时间：
2005-01-01
影响因子：
2.1
作者：
Collin, P;Kaukinen, K;Mäki, M
通讯作者：
Mäki, M
影响因子：
120.7
作者：
Catassi, C;Fabiani, E;Corazza, GR
通讯作者：
Corazza, GR
影响因子：
29.4
作者：
Askling, J;Linet, M;Ekbom, A
通讯作者：
Ekbom, A
影响因子：
82.9
作者：
Anderson, RP;Degano, P;Hill, AVS
通讯作者：
Hill, AVS