Chitosan: a highly efficient renewable and recoverable bio-polymer catalyst for the expeditious synthesis of α-amino nitriles and imines under mild conditions
Chitosan: a highly efficient renewable and recoverable bio-polymer catalyst for the expeditious synthesis of α-amino nitriles and imines under mild conditions
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DOI：
10.1039/c3gc36901c
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发表时间：
2013-01-01
期刊：
影响因子：
9.8
通讯作者：
Ramezani, Leila
中科院分区：
文献类型：
--
作者：
Dekamin, Mohammad G.;Azimoshan, Mojtaba;Ramezani, Leila
商业壳聚糖——未经任何活性布朗斯台德或路易斯酸中心的后修饰——被发现是一种高效的可再生和可回收的生物聚合物催化剂，用于在室温下温和的反应条件下以高定量产率快速方便地从芳香醛和胺合成α-氨基腈或亚胺。使用三甲基氰硅烷（TMSCN）通过 Strecker 反应制备α-氨基腈衍生物，并在壳聚糖作为非均相双功能有机催化剂的催化下制备。
Commercial chitosan - without any post-modification with active Bronsted or Lewis acid centers - was found to be a highly efficient renewable and recoverable bio-polymer catalyst for the rapid and convenient synthesis of alpha-amino nitriles or imines from aromatic aldehydes and amines under mild reaction conditions at room temperature in high to quantitative yields. The alpha-amino nitrile derivatives were prepared through the Strecker reaction using trimethylsilyl cyanide (TMSCN) and catalyzed by chitosan as a heterogeneous bifunctional organocatalyst.