Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters
Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters
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DOI：
10.1557/adv.2017.634
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发表时间：
2018-01-01
期刊：
影响因子：
0.8
通讯作者：
Peeters, M.
中科院分区：
文献类型：
--
作者：
Betlem, Kai;Down, Michael P.;Peeters, M.
我们已经开发出对多巴胺、去甲肾上腺素和咖啡因等神经递质具有高亲和力的分子印迹聚合物(MIP)。这些聚合物颗粒混合在丝网印刷油墨的主体中，从而实现了可批量生产的改性MIP丝网印刷电极(MIP-SPE)。我们探索了不同的SPE支撑面，如聚酯、示踪纸和家用打印纸。利用已获专利的热传递方法(HTM)对这些MIP-SPE的性能进行了研究。结合丝网印刷技术和热检测技术，有可能开发出一种便携式传感器平台，能够现场低成本、直接地检测生物分子。在未来，这种独特的传感器架构为生物医学设备的使用带来了巨大的希望。
We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink allowing masss-producible bulk modified MIP Screen-Printed Electrodes (MIP-SPEs) to be realised. We have explored different SPE supporting surfaces, such as polyester, tracing paper and household-printing paper. The performance of those MIP-SPEs is studied using the Heat-Transfer Method (HTM), a patented thermal method. With the combination of screen-printing techniques and thermal detection, it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules on-site. In the future, this unique sensor architecture holds great promise for the use in biomedical devices.