Effects of aromatizable and nonaromatizable androgens on the sex inversion of red-spotted grouper (Epinephelus akaara).
Effects of aromatizable and nonaromatizable androgens on the sex inversion of red-spotted grouper (Epinephelus akaara).
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可芳香和非原子化雄激素对红斑点斑点（Epinephelus akaara）的性反转的影响。
DOI：
10.1007/s10695-005-4900-z
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发表时间：
2006-03
影响因子：
2.9
通讯作者：
Lin, Hao-Ran
中科院分区：
文献类型：
--
作者：
Li, Guang-Li;Liu, Xiao-Chun;Lin, Hao-Ran
关键词：
The effects of aromatizable 17α-methyltestosterone (MT) and non-aromatizable 17α-methyldihydrotestosterone (MDHT) on sex inversion in red-spotted grouper, Epinephelus akaara, were investigated. Fish were implanted with MT, MDHT and MT+AI (aromatase inhibitor, AI) respectively for one month. The results showed that the three treated groups turned into transitional stage with intersex gonads, which contained atretic oocytes and spermatogenic germ cells at all stages of spermatogenesis. The controls did not change sex. The gonads of more than half MT-implanted fish were in early transitional stages of sex inversion, whereas those of more than half MDHT and MT+AI-implanted fish were in late transitional stages of sex inversion. No difference in serum estradiol-17β (E2) levels between the controls and the treated groups were observed, whereas 11-ketotestosterone (11-KT) and testosterone (T) levels increased in all treated groups. Significantly lower gonadosomatic index (GSI) and gonadal aromatase activity were observed in the treated groups, which were in accordance with the lower mRNA expression of P450aromA. However, P450aromB mRNA expression increased in the MT group, while it did not change in the MDHT group. These results suggest that the sex inversion of red-spotted grouper by MT and MDHT implantation might be due to the suppression of P450aromA gene expression, and resulting in both the decrease of the ovarian estrogen –secretion, as well as the increase in the 11-KT levels. Furthermore, the main reason for MT being less effective than MDHT might be due to partial aromatization of MT to estrogen.
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DOI：
10.1016/s0960-0760(01)00147-9
发表时间：
2001-12-01
影响因子：
4.1
作者：
Callard, GV;Tchoudakova, AV;Wood, E
通讯作者：
Wood, E
影响因子：
2
作者：
Blázquez, M;Felip, A;Piferrer, F
通讯作者：
Piferrer, F
影响因子：
1
作者：
Galbreath, PF;Adams, ND;Sherrill, LW
通讯作者：
Sherrill, LW
影响因子：
4.5
作者：
Gale, WL;Fitzpatrick, MS;Schreck, CB
通讯作者：
Schreck, CB
影响因子：
2.9
作者：
PIFERRER, F;DONALDSON, EM
通讯作者：
DONALDSON, EM