Propranolol withdrawal in angina pectoris: a prospective study.
Propranolol withdrawal in angina pectoris: a prospective study.
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心绞痛中的普萘洛尔戒断：一项前瞻性研究。
DOI：
10.1016/0002-8703(79)90428-9
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发表时间：
1979
影响因子：
4.8
通讯作者：
G. Wisenberg
中科院分区：
文献类型：
--
作者：
Martin G. Myers;Michael R Freeman;Zulfikar A Juma;G. Wisenberg
在一项前瞻性研究中，100名心绞痛患者(平均年龄51.3岁)在择期冠状动脉造影术前24至144小时(平均39.0小时)突然停用心得安。平均疗程8.2月，平均每日心得安剂量216.1 mg。纽约心脏协会II级、III级和IV级症状分别为30例、41例和29例，1、2、3支冠状动脉狭窄超过50%的分别为37例、29例和34例。3例患者在预定的停止治疗时间之前胸痛轻微增加，2例发生非穿壁性心肌梗死。在停药后期间发生的轻微和严重并发症的数量相同。在这项研究中，所有四名发生非穿壁性心肌梗死的患者都有预先存在的IV级症状。其余90名患者的病程都很顺利。这些发现不支持心得安回升停药反应的概念。
In a prospective study, 100 consecutive patients (mean age 51.3 years) with angina pectoris had propranolol abruptly discontinued 24 to 144 hours (mean 39.0 hours) prior to elective coronary arteriography. The mean duration of therapy was 8.2 months and the mean daily propranolol dose was 216.1 mg. New York Heart Association Class II, III and IV symptoms were present in 30, 41, and 29 patients and one, two, or three coronary arteries were more than 50 per cent narrowed in 37, 29, and 34 cases, respectively.Three patients experienced minor increases in chest pain and two suffered non-transmural myocardial infarctions prior to the time of scheduled cessation of therapy. The same number of minor and major complications occurred in the post-withdrawal period. All four patients who developed non-transmural myocardial infarction in this study had pre-existing Class IV symptoms. The course of the remaining 90 patients was uneventful. These findings do not support the concept of a rebound propranolol withdrawal reaction.