The structure and function of thioester-containing proteins in arthropods.
The structure and function of thioester-containing proteins in arthropods.
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DOI：
10.1007/s12551-014-0142-6
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发表时间：
2014-12
影响因子：
--
通讯作者：
Baxter R
中科院分区：
文献类型：
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作者：
Williams M;Baxter R
含硫酯蛋白（TEPs）是一个古老而多样的分泌蛋白家族，在先天免疫反应中起着重要作用。TEPs的两个家族，补体因子和α2-巨球蛋白，已经在脊椎动物中被发现和研究多年，但直到最近十年才获得晶体结构。在同一时期，在节肢动物中发现了另外两类TEPs。在这篇综述中，我们讨论了TEPs的共同结构特征，以及如何将这些知识应用于许多功能未知的节肢动物TEPs。TEPs执行各种各样的功能，这些功能由不同的四级结构和一组共同的折叠结构域之间的蛋白质-蛋白质相互作用驱动。一个共同的主题是由蛋白质水解引发的受调节的构象变化。对不同节肢动物TEPs的结构-功能分析不仅可以确定先天免疫的新机制，还可以确定免疫、发育和细胞死亡之间的界面。
Thioester-containing proteins (TEPs) form an ancient and diverse family of secreted proteins that play central roles in the innate immune response. Two families of TEPs, complement factors and α2-macroglobulins, have been known and studied in vertebrates for many years, but only in the last decade have crystal structures become available. In the same period, the presence of two additional classes of TEPs has been revealed in arthropods. In this review, we discuss the common structural features TEPs and how this knowledge can be applied to the many arthropod TEPs of unknown function. TEPs perform a wide variety of functions that are driven by different quaternary structures and protein–protein interactions between a common set of folded domains. A common theme is regulated conformational change triggered by proteolysis. Structure-function analysis of the diverse arthropod TEPs may identify not just new mechanisms in innate immunity but also interfaces between immunity, development and cell death.