Increase of success rate for women undergoing embryo transfer by transcutaneous electrical acupoint stimulation: a prospective randomized placebo-controlled study
Increase of success rate for women undergoing embryo transfer by transcutaneous electrical acupoint stimulation: a prospective randomized placebo-controlled study
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经皮穴位电刺激提高女性胚胎移植的成功率：一项前瞻性随机安慰剂对照研究
DOI：
10.1016/j.fertnstert.2011.07.1093
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发表时间：
2011-10-01
影响因子：
6.7
通讯作者：
Han, Ji-Sheng
中科院分区：
文献类型：
--
作者：
Zhang, Rong;Feng, Xiao-Jun;Han, Ji-Sheng
目的：评估经皮穴位电刺激（TEAS）对接受ET的女性妊娠率（PR）的影响。设计：前瞻性、随机、单盲安慰剂对照临床试验。设置：研究和实验室设施。患者：共有309名患者，年龄小于45岁，接受冷冻保存胚胎移植或新鲜周期IVF，有或没有卵胞浆内单精子注射（ICSI）。干预：受试者随机分为三组：模拟TEAS处理：ET后30分钟（组I，n = 99）;单次TEAS治疗：ET后30分钟（II组，n = 110）和双TEAS治疗：ET前24小时和ET后30分钟（III组，n = 100）。主要结果测量：临床PR、胚胎植入率、活产率。结果：I组的临床PR、胚胎种植率和活产率（分别为29.3%、15.0%和21.2%）显著低于II组结论：经皮穴位电刺激，尤其是双TEAS，能明显改善ET的临床疗效。（Fertil Steril（R）2011; 96：912-6.（C）2011年由美国生殖医学协会。
Objective: To evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on pregnancy rates (PR) in women undergoing ET.Design: Prospective, randomized, single-blinded placebo-controlled clinical trial.Setting: Research and laboratory facilities.Patient(s): A total of 309 patients, less than 45 years old, undergoing cryopreservation embryos transplant or fresh cycle IVF with or without intracytoplasmic sperm injection (ICSI).Intervention(s): The subjects were randomly allocated to three groups: mock TEAS treatment: 30 minutes after ET (group I, n = 99); single TEAS treatment: 30 minutes after ET (group II, n = 110); and double TEAS treatments: 24 hours before ET and 30 minutes after ET (group III, n = 100).Main Outcome Measure(s): Clinical PR, embryos implantation rate, live birth rate.Result(s): The clinical PR, embryos implantation rate, and live birth rate of group I (29.3%, 15.0%, and 21.2%, respectively) were significantly lower than those in group II (42.7%, 25.7%, and 37.3%, respectively) and group III (50.0%, 25.9%, and 42.0%, respectively).Conclusion(s): Transcutaneous electrical acupoint stimulation, especially double TEAS, significantly improved the clinical outcome of ET. (Fertil Steril (R) 2011; 96: 912-6. (C)2011 by American Society for Reproductive Medicine.)