Sensation-seeking-related DNA methylation and the development of delinquency: A longitudinal epigenome-wide study.
Sensation-seeking-related DNA methylation and the development of delinquency: A longitudinal epigenome-wide study.
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与感觉寻求相关的 DNA 甲基化和犯罪的发展：一项纵向表观基因组研究。
DOI：
10.1017/s0954579422000049
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发表时间：
2023
影响因子：
3.3
通讯作者：
Barker,EdwardD
中科院分区：
文献类型：
--
作者：
Tieskens,JacinthaM;vanLier,PolAC;Buil,JMarieke;Barker,EdwardD
强烈的感觉寻求与犯罪的发展有关。此外，感觉寻求，或感觉寻求的生物学关联，被认为是将受害与犯罪联系起来的因素。在这里，我们关注的是感觉寻求的表观遗传相关性。首先，我们确定了与感觉寻求相关的DNA甲基化(DNaM)模式。其次，我们调查了与感觉寻求相关的dNaM与犯罪的发展之间的关系。第三，我们考察了受害是否与寻求感觉相关的dNaM和犯罪的发展有关。参与者(N=905；49%男孩)来自雅芳亲子纵向研究。DNaM在出生时、7岁和15-17岁时进行评估。感觉寻求(自我报告)在11岁和14岁时评估。犯罪(自我报告)在17-19岁时评估。感觉寻求表观基因组关联研究表明没有探针达到临界显著水平。然而，20个差异甲基化探针达到了边际意义。使用这20个提示性站点，创建了寻求感觉的累积dNaM风险分数。结果表明，15-17岁的dNaM风险评分与17-19岁的犯罪有关。此外，通过dNaM发现受害对犯罪的间接影响。与感觉寻求相关的dNaM是一种潜在的生物学关联，可以帮助理解犯罪的发展，包括受害可能如何与青少年犯罪相关。
Heightened sensation-seeking is related to the development of delinquency. Moreover, sensation-seeking, or biological correlates of sensation-seeking, are suggested as factors linking victimization to delinquency. Here, we focused on epigenetic correlates of sensation-seeking. First, we identified DNA methylation (DNAm) patterns related to sensation-seeking. Second, we investigated the association between sensation-seeking related DNAm and the development of delinquency. Third, we examined whether victimization was related to sensation-seeking related DNAm and the development of delinquency. Participants (N = 905; 49% boys) came from the Avon Longitudinal Study of Parents and Children. DNAm was assessed at birth, age 7 and age 15–17. Sensation-seeking (self-reports) was assessed at age 11 and 14. Delinquency (self-reports) was assessed at age 17–19. Sensation-seeking epigenome-wide association study revealed that no probes reached the critical significance level. However, 20 differential methylated probes reached marginal significance. With these 20 suggestive sites, a sensation-seeking cumulative DNAm risk score was created. Results showed that this DNAm risk score at age 15–17 was related to delinquency at age 17–19. Moreover, an indirect effect of victimization to delinquency via DNAm was found. Sensation-seeking related DNAm is a potential biological correlate that can help to understand the development of delinquency, including how victimization might be associated with adolescent delinquency.