REAL-COLOR VERSUS PSEUDO-COLOR IMAGING OF FIBROTIC SCARS IN EXUDATIVE AGE-RELATED MACULAR DEGENERATION
REAL-COLOR VERSUS PSEUDO-COLOR IMAGING OF FIBROTIC SCARS IN EXUDATIVE AGE-RELATED MACULAR DEGENERATION
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DOI：
10.1097/iae.0000000000002771
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发表时间：
2020-12-01
影响因子：
3.3
通讯作者：
Souied, Eric H.
中科院分区：
文献类型：
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作者：
De Rosa, Irene;Ohayon, Avi;Souied, Eric H.
目的：采用多色（MC）成像、彩色眼底照相（CFP）和超广角CFP（UWFCFP）比较晚期年龄相关性黄斑变性视网膜下纤维化的形态特征。方法：纳入31例诊断为视网膜下纤维化并发渗出性年龄相关性黄斑变性患者的32只眼。所包括的眼睛通过 MC、CFP 和 UWFCFP 进行成像。两名读者使用评分（0：不可见，1：几乎不可见，2：大部分可见，3：完全可见）对纤维化、其边缘以及与周围萎缩的差异性进行可视化的整体能力进行分级。计算纤维化面积。所有三种成像技术的缩放、病变共定位以及面积测量均使用 ImageJ 进行。结果：对 32 只眼睛的 96 幅图像进行了分级。 MC 的纤维化平均面积为 14.59 +/- 8.94 mm(2)，CFP 为 13.84 +/- 8.56 mm(2)，UWFCFP 为 13.76 +/- 8.79 mm(2)。使用 MC 时，纤维化在 87.5% 的病例中完全可见，而使用 CFP 和 UWFCFP 时，纤维化程度为 50%。 40.6% 的 MC 眼、15.6% 的 CFP 眼和 9.4% 的 UWFCFP 眼中纤维化边缘清晰。多色成像可以更好地区分纤维化和萎缩（MC 为 100%，CFP 为 13.4%，UWFCFP 为 33.3%）。所有测量的阅读器间和阅读器内一致性都很高（P < 0.0001）。结论：与 CFP 和 UWFCFP 相比，多色技术可以改善视网膜下纤维化的可视化和分析，特别是当存在周围萎缩时。
Purpose: To compare the morphological characteristics of subretinal fibrosis in late age-related macular degeneration using multicolor (MC) imaging, color fundus photography (CFP), and ultra-widefield CFP (UWFCFP).Methods: Thirty-two eyes of 31 patients diagnosed with subretinal fibrosis complicating exudative age-related macular degeneration were included. Included eyes were imaged by MC, CFP, and UWFCFP. The overall ability to visualize fibrosis, its margins, and dissimilarity with surrounding atrophy was graded using a score (0: not visible, 1: barely visible, 2: mostly visible, and 3: fully visible) by two readers. Area of fibrosis was calculated. Scaling, lesion colocalization on all three imaging techniques, and area measurements were performed using ImageJ.Results: Ninety-six images of 32 eyes were graded. The average area of fibrosis was 14.59 +/- 8.94 mm(2) for MC, 13.84 +/- 8.56 mm(2) for CFP, and 13.76 +/- 8.79 mm(2) for UWFCFP. Fibrosis was fully visible in 87.5% of cases using MC and 50% using CFP and UWFCFP. Fibrosis' margins were sharply defined in 40.6% of eyes with MC, 15.6% and 9.4% with CFP and UWFCFP, respectively. Multicolor imaging provided superior distinction between fibrosis and atrophy (100% for MC vs. 13.4% for CFP and 33.3% for UWFCFP). The inter- and intra-reader agreement was high for all measurements (P < 0.0001).Conclusion: Multicolor technology allows for improved visualization and analysis of subretinal fibrosis when compared with CFP and UWFCFP, especially when surrounding atrophy is present.