Rat cytomegalovirus infection enhances type II collagen arthritis in rats.
Rat cytomegalovirus infection enhances type II collagen arthritis in rats.
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大鼠巨细胞病毒感染可增强大鼠 II 型胶原关节炎。
DOI：
10.1002/art.1780291012
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发表时间：
1986
影响因子：
--
通讯作者：
Wei,LS
中科院分区：
文献类型：
--
作者：
Smith,CB;Griffiths,MM;Wei,LS
在 DA 大鼠中研究了大鼠巨细胞病毒 (RCMV) 感染对 II 型胶原诱导的关节炎的影响。在用小牛II型胶原免疫之前5天、同时或之后5天，使大鼠感染RCMV。对照大鼠要么单独给予II型胶原蛋白，要么在胶原蛋白免疫的同时注射正常大鼠唾液腺(NRSG)。每个肢体的关节炎严重程度按 1-4 级评分（最高分为 16 分）。在 5 个实验中，RCMV 组的关节炎峰值评分是仅接受 NRSG 或胶原蛋白的对照组的两倍（8-9 与 4-6）。受累关节的射线照片显示，与 NRSG 对照组相比，RCMV 大鼠的软骨和关节骨受到更大的破坏。多次尝试从关节组织中培养 RCMV，但均未成功。我们的结果表明，RCMV 感染增强了自身免疫性关节炎实验模型中的关节炎过程。
The effect of rat cytomegalovirus (RCMV) infection on type II collagen‐induced arthritis was studied in DA rats. Rats were infected with RCMV 5 days before, simultaneously with, or 5 days after immunization with calf type II collagen. Control rats were either given type II collagen alone or were injected with normal rat salivary gland (NRSG) simultaneously with collagen immunization. Severity of arthritis in each limb was graded on a scale of 1–4 (maximum score 16). In 5 experiments, peak arthritis scores in the RCMV groups were twice those of the control groups which received NRSG or collagen only (8–9 versus 4–6). Radiographs of involved joints showed greater destruction of cartilage and articular bone in the RCMV rats than in the NRSG control group. Repeated attempts to culture RCMV from joint tissues were unsuccessful. Our results indicate that RCMV infection enhances the arthritic process in this experimental model of an autoimmune arthritis.