Sputum eosinophilia in idiopathic pulmonary fibrosis
Sputum eosinophilia in idiopathic pulmonary fibrosis
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DOI：
10.1007/s00011-004-1321-x
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发表时间：
2005-02-01
影响因子：
6.7
通讯作者：
Bradding, P
中科院分区：
文献类型：
--
作者：
Birring, SS;Parker, D;Bradding, P
目标和设计：咳嗽是特发性肺纤维化的常见症状，难以治疗并对生活质量产生重大影响。我们在一项前瞻性横断面研究中检验了特发性肺纤维化患者的咳嗽和咳嗽反射敏感性增加可能是由于气道炎症引起的假设。 对象和方法：我们测量了 15 名特发性肺纤维化患者、17 名健康对照者和 15 名慢性阻塞性肺病患者的诱导痰液炎症细胞谱和无细胞上清液炎症介质浓度。 结果：痰液差异的几何平均数特发性肺纤维化患者的嗜酸性粒细胞计数和中位嗜酸性粒细胞阳离子蛋白浓度显着高于对照组（分别为 2.1% vs 0.3%；p < 0.001 和 1.1 mg/ml vs 0.2 mg/ml；p = 0.03）。特发性肺纤维化和慢性阻塞性肺疾病患者的痰嗜酸性粒细胞计数和嗜酸性粒细胞阳离子蛋白浓度没有显着差异。与对照组相比，特发性肺纤维化 (p = 0.03) 和慢性阻塞性肺疾病 (p = 0.008) 患者的痰液白三烯-B4 浓度显着降低。结论：特发性肺纤维化的特点是存在活动性嗜酸性粒细胞气道炎症，这增加了气道炎症可能导致咳嗽等症状的可能性。
Objectives and Design: Cough is a common symptom in idiopathic pulmonary fibrosis that is difficult to treat and has a major impact on quality of life. We tested the hypothesis that the cough and increased cough reflex sensitivity seen in patients with idiopathic pulmonary fibrosis may be due to airway inflammation in a prospective, cross-sectional study.Subjects and Methods: We measured the induced sputum inflammatory cell profile and cell-free supernatant inflammatory mediator concentrations in 15 patients with idiopathic pulmonary fibrosis, 17 healthy controls and 15 patients with chronic obstructive pulmonary disease.Results: Both the geometric mean sputum differential eosinophil cell count and median eosinophilic-cationic-protein concentration were significantly higher in patients with idiopathic pulmonary fibrosis than controls (2.1% vs 0.3%; p < 0.001 and 1.1 mg/ml versus 0.2 mg/ ml; p = 0.03 respectively). There were no significant differences in sputum eosinophil counts and eosinophilic-cationic-protein concentrations between patients with idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Sputum leukotriene-B4 concentrations were significantly lower in patients with idiopathic pulmonary fibrosis ( p = 0.03) and chronic obstructive pulmonary disease ( p = 0.008) compared to controls.Conclusions: Idiopathic pulmonary fibrosis is characterised by the presence of active eosinophilic airway inflammation raising the possibility that airway inflammation may contribute to symptoms such as cough.