Acute leukemia with Burkitt's tumor cells: A study of six cases with special reference to lymphocyte surface markers.
Acute leukemia with Burkitt's tumor cells: A study of six cases with special reference to lymphocyte surface markers.
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伯基特肿瘤细胞引起的急性白血病：六例病例的研究，特别涉及淋巴细胞表面标记。
DOI：
10.1182/blood.v45.2.183.183
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发表时间：
1975
期刊：
影响因子：
20.3
通讯作者：
J. Preud’homme
中科院分区：
文献类型：
--
作者：
G. Flandrin;J. Brouet;M. Daniel;J. Preud’homme
在6例急性白血病患者（约2%的患者被称为急性淋巴细胞白血病）的原始细胞侵入骨髓和血液显示伯基特肿瘤细胞的所有细胞学，细胞化学和电子显微镜特征。单克隆表面免疫球蛋白的存在（其合成被证明在体外培养实验），IgG聚集体的结合，以及玫瑰花结形成的情况下，与绵羊红细胞记录这些原始细胞的单克隆B细胞起源，这是在形成鲜明对比的结果，在常见的急性淋巴细胞白血病。病程通常迅速致死，无化疗诱导的缓解。
In six patients with acute leukemia (about 2% of the patients referred for acute lymphoblastic leukemia) the blast cells invading bone marrow and blood showed all the cytologic, cytochemical, and electron microscopy features of Burkitt's tumor cells. The presence of monoclonal surface immunoglobulins (their synthesis being proved by in vitro culture experiments), the binding of IgG aggregates, and the absence of rosette formation with sheep red cells documented the monoclonal B-cell origin of these blast cells which is in sharp contrast to the findings in common acute lymphoblastic leukemia. The course of the disease was usually rapidly fatal without chemotherapy-induced remission.