Preparation of porous polylactide microspheres by emulsion-solvent evaporation based on solution induced phase separation
Preparation of porous polylactide microspheres by emulsion-solvent evaporation based on solution induced phase separation
复制标题
基于溶液诱导相分离的乳液-溶剂蒸发制备多孔聚丙交酯微球
DOI：
10.1002/pat.629
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发表时间：
2005-08-01
影响因子：
3.4
通讯作者：
Shen, JC
中科院分区：
文献类型：
--
作者：
Hong, Y;Gao, CY;Shen, JC
采用溶液诱导相分离的乳液-溶剂蒸发法制备了多孔聚乳酸微球。扫描电镜（SEM）观察证实了微球的多孔结构，具有良好的连通性。孔隙大小在十微米范围内。除了在非多孔微球上存在类似的大空腔外，在多孔微球表面发现了小孔隙。多孔微球的表观密度比非多孔微球小得多。搅拌速率、良好的溶剂/非溶剂比、聚乳酸浓度、分散剂（聚乙烯醇、PVA）浓度等制备条件对微球的粒径、粒径分布和孔径均有重要影响。在较慢的搅拌速度、较低的好溶剂/非溶剂比或较低的聚乳酸浓度下，由于较长的聚结时间，可以获得较大的孔径。版权所有©2005 John Wiley & Sons， Ltd
Porous polylactide (PLA) microspheres were fabricated by an emulsion-solvent evaporation method based on solution induced phase separation. Scanning electron microscopy (SEM) observations confirmed the porous structure of the microspheres with good connectivity. The pore size was in the range of decade micrometers. Besides large cavities as similarly existed on non-porous microspheres, small pores were found on surfaces of the porous microspheres. The apparent density of the porous microspheres was much smaller than that of non-porous microspheres. Fabrication conditions such as stirring rate, good solvent/non-solvent ratio, PLA concentration and dispersant (polyvinyl alcohol, PVA) concentration had an important influence on both the particle size and size distribution and the pore size within the microspheres. A larger pore size was achieved at a slower stirring rate, lower good solvent/non-solvent ratio or lower PLA concentration due to longer coalescence time. Copyright © 2005 John Wiley & Sons, Ltd.