Neural dysfunction in ADHD with Reading Disability during a word rhyming Continuous Performance Task.
Neural dysfunction in ADHD with Reading Disability during a word rhyming Continuous Performance Task.
复制标题
在押韵连续表现任务期间，多动症患者的神经功能障碍和阅读障碍。
DOI：
10.1016/j.bandc.2015.04.009
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发表时间：
2015
影响因子：
2.5
通讯作者：
Stanley,JA
中科院分区：
文献类型：
--
作者：
Mohl,B;Ofen,N;Jones,LL;Robin,AL;Rosenberg,DR;Diwadkar,VA;Casey,JE;Stanley,JA
注意缺陷/多动障碍（ADHD）是一种异质性的神经发育障碍，通常与阅读障碍（RD）共同发生。与正常发展的对照组相比，患有或不患有RD的ADHD患者的注意力不集中评分始终较高，同时出现ADHD和RD的患者也表现出语音处理受损。因此，注意力不集中与更严重的语音障碍有关，尽管从功能神经影像学的角度来看，这种联系的神经相关性尚不清楚。假设与对照相比，只有共同发生的亚组会表现出左后脑半球阅读相关区域的低激活，以及在较小程度上右脑半球注意力区域的改变。方法采用一种新颖的单词押韵连续表现任务来评估三组儿童在语音和注意力相关区域的功能激活差异：10名ADHD合并RD的男孩，14名ADHD非RD的男孩和14名正常发展的对照组。受试者对与目标单词押韵的单词的反应为单音节和双音节，英语单词在视觉上呈现超过90个块。结果两组患者的行为表现无显著差异。与对照组相比，ADHD和RD患者的左半球阅读相关区域明显失活，但没有RD的ADHD患者则没有。与对照组相比，两个ADHD亚组的右半球注意区域都出现了变化；然而，每个亚组的差异是不同的。结论ADHD合并阅读障碍患者的背侧解码子网络可能没有严重受损。认知障碍的作用，包括注意力不集中的程度，需要从神经影像学的角度来澄清。
BackgroundAttention-Deficit/Hyperactivity Disorder (ADHD) is a heterogeneous, neurodevelopmental disorder which co-occurs often with Reading Disability (RD). ADHD with and without RD consistently have higher inattentive ratings compared with typically developing controls, with co-occurring ADHD and RD also demonstrating impaired phonological processing. Accordingly, inattention has been associated with greater phonological impairment, though the neural correlates of the association are poorly understood from a functional neuroimaging perspective. It was postulated that only the co-occurring subgroup would demonstrate hypoactivation of posterior, left hemispheric, reading-related areas and, to a lesser extent, alterations in right hemispheric, attention areas compared with controls.MethodsA novel word rhyming Continuous Performance Task assesses functional activation differences in phonology- and attention-related areas between three groups: ten boys with ADHD and RD, fourteen boys with ADHD without RD, and fourteen typically developing controls. Subjects respond to words that rhyme with a target word as mono- and disyllabic, English words are visually presented over 90 s blocks.ResultsBehavioral performance was not different between groups. Some hypoactivation of left hemispheric, reading-related areas was apparent in ADHD and RD, but not ADHD without RD, compared with controls. Right hemispheric, attention areas showed alterations in both ADHD subgroups relative to controls; however, the differences for each subgroup were dissimilar.ConclusionsThe dorsal decoding subnetwork may not be grossly compromised in ADHD with Reading Disability. The role of cognitive impairments, including the level of inattention, on phonology requires clarification from a neuroimaging perspective.