Metabolic biomarkers related to oxidative stress and antioxidant status in Saudi autistic children
Metabolic biomarkers related to oxidative stress and antioxidant status in Saudi autistic children
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DOI：
10.1016/j.clinbiochem.2009.03.011
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发表时间：
2009-07-01
影响因子：
2.8
通讯作者：
Al-Ayadhi, L.
中科院分区：
文献类型：
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作者：
Al-Gadani, Y.;EI-Ansary, A.;Al-Ayadhi, L.
目的：沙特自闭症儿童氧化应激和抗氧化相关参数（酶和非酶）的测量设计和方法：30名自闭症儿童（22名男性和8名女性），年龄3-15岁（其中25/30是8岁以下），30名健康儿童作为对照组被纳入本研究。过氧化脂质，维生素E，维生素C，谷胱甘肽的水平，谷胱甘肽过氧化物酶（GSH-Px）的酶活性，和过氧化氢酶测定血浆中，而超氧化物歧化酶（SOD）测定红细胞中的两个group.Results：脂质过氧化被认为是显着高于自闭症相比，控制沙特儿童。另一方面，维生素E和谷胱甘肽在自闭症患者中显着降低，而维生素C显示出不显着的低值。关于酶的抗氧化剂，谷胱甘肽过氧化物酶（GSH-Px）和超氧化物歧化酶（SOD）显着较高的自闭症相比，控制，而过氧化氢酶记录或多或少类似的活动，在两个group.Conclusion：沙特自闭症儿童H2 O2压力下，由于GSH耗尽，超氧化物歧化酶的表达与不变的过氧化氢酶。这可能有助于早期诊断的年轻自闭症患者，并建议抗氧化剂补充的早期干预自闭症儿童的可能性。(c)2009年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objective: Measurement of oxidative stress and antioxidant-related parameters (enzymatic and non-enzymatic) in Saudi autistic children.Design and methods: 30 autistic children (22 males and 8 females) aged 3-15 years (25/30 of these were below 8 years old), and 30 healthy children as control group were included in this study. Levels of lipid peroxides, vitamin E, vitamin C, glutathione together with enzymatic activities of glutathione peroxidase (GSH-Px), and catalase were determined in plasma while superoxide dismutase (SOD was measured in red blood cells of both groups.Results: Lipid peroxidation was found to be significantly higher in autistic compared to control Saudi children. On the other hand, vitamin E and glutathione were remarkably lower in autistic patients while vitamin C shows non-significant lower values. Regarding the enzymatic antioxidants, both glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were significantly higher in autistic compared to control while catalase recorded more or less similar activities in both groups.Conclusion: Saudi autistic children are under H2O2 stress due to GSH depletion, over expression of SOD together with the unchanged catalase enzyme. This could be helpful in the early diagnosis of young autistic patients and suggesting the possibility of antioxidant supplementation for the early intervention with autistic children. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.