EFFECT OF VIRAL RESPIRATORY-TRACT INFECTION ON OUTCOME OF ACUTE OTITIS-MEDIA
EFFECT OF VIRAL RESPIRATORY-TRACT INFECTION ON OUTCOME OF ACUTE OTITIS-MEDIA
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DOI：
10.1016/s0022-3476(05)81950-x
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发表时间：
1992-06-01
影响因子：
5.1
通讯作者：
HOWIE, VM
中科院分区：
文献类型：
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作者：
CHONMAITREE, T;OWEN, MJ;HOWIE, VM
我们前瞻性研究了271名患有急性中耳炎（AOM）的婴儿和儿童（2个月至7岁）的病毒和细菌原因，治疗结束时的结果以及1个月内复发的频率。全面的病毒学方法，包括病毒抗原检测、细胞培养和血清学研究，用于诊断呼吸道、中耳或两者的病毒感染。在46%（124/271）的AOM患者中发现了病毒感染的证据。66名患者（24%）中耳液中有病毒或病毒抗原;其中50名患者（76%）中耳液中也有细菌，16名（24%）仅有病毒。与单纯细菌性中耳炎（35%; p = 0.05）或单纯病毒感染（19%; p = 0.05）的患者相比，合并细菌和病毒感染的AOM患者（51%）有更多的持续性中耳炎（抗生素治疗后3 - 12天）。
We prospectively studied 271 infants and children (2 months to 7 years of age) with acute otitis media (AOM) for viral and bacterial causes, outcome at the end of therapy, and frequency of recurrence within 1 month. Comprehensive virologic methods, including viral antigen detection, cell culture, and serologic studies, were used to diagnose viral infection of the respiratory tract, middle ear, or both. Evidence of viral infection was found in 46% (124/271) of patients with AOM. Sixty-six patients (24%) had virus or viral antigen in the middle ear fluid; 50 of these patients (76%) also had bacteria in middle ear fluid, and 16 (24%) had virus alone. More patients with AOM and combined bacterial and viral infection (51%) had persistent otitis (3 to 12 days after institution of antibiotic treatment), compared with those with only bacterial otitis (35%; p = 0.05) or patients with only viral infection (19%; p