Patterns of variability of retinol levels in a harbour porpoise population from an unpolluted environment
Patterns of variability of retinol levels in a harbour porpoise population from an unpolluted environment
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未污染环境中港湾鼠海豚种群视黄醇水平的变异模式
DOI：
10.3354/meps185085
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发表时间：
1999
影响因子：
2.5
通讯作者：
Bert Spenkelink
中科院分区：
文献类型：
--
作者：
A. Borrell;G. Cantos;Alex Aguilar;Christina Lockyer;Abraham Brouwer;M. Heide‐Jørgensen;J. Jensen;Bert Spenkelink
已知有机氯化合物（OC）可诱导哺乳动物维生素A（类维生素A）缺乏，这可能与免疫能力、生殖和生长的损害有关。这使得类维生素A成为有机氯对海洋哺乳动物影响的潜在有用的生物标志物。然而，使用类维生素A作为生物标志物需要了解其在自然条件下的种群内变异模式，目前还没有这些信息。我们调查了生活在未污染环境中的鲸类种群的这些模式。在1995年狩猎季节，对来自西格陵兰的100头港鼠海豚Phocoena phocoena进行了采样。性别，年龄，形态测量，营养状况，和视黄醇（皂化后）和OC水平的鲸脂进行了测定，为每个人。发现的有机碳水平极低，因此被认为不太可能对种群产生不利影响：以可提取物为基础，多氯联苯的平均鲸脂浓度为百万分之2.04（标准差= 1.1），总滴滴涕为百万分之2.76（标准差= 1.66）。总体鲸脂中视黄醇的平均浓度为59.66（SD = 45.26）μg g-1。考虑到鲸脂对身体质量的高贡献，鲸脂构成了维甲酸沉积在港湾鼠海豚的重要身体部位。视黄醇浓度在地理区域或性别之间没有显著差异，但与年龄显著相关（p < 0.001）。通过测定鲸脂的脂质含量来测量身体状况，对视黄醇水平没有显着影响，但被检查的个体被认为处于整体良好的营养状况。它的结论是，测量鲸脂样品中的视黄醇浓度是可行的，并有可能作为生物标志物的鲸目动物的有机氯暴露。然而，为了做到这一点，生物信息，特别是年龄，对于正确评估生理影响至关重要。
Organochlorine compounds (OC) are known to induce vitamin A (retinoids) deficiency in mammals, which may be associated with impairment of immunocompetence, reproduction and growth. This makes retinoids a potentially useful biomarker of organochlorine impact on marine mammals. However, use of retinoids as a biomarker requires knowledge about its intrapopulation patterns of variation in natural conditions, information which is not currently available. We investigated these patterns in a cetacean population living in an unpolluted environment. 100 harbour porpoises Phocoena phocoena from West Greenland were sampled during the 1995 hunting season. Sex, age, morphometrics, nutritive condition, and retinol (following saponification) and OC levels in blubber were determined for each individual. OC levels found were extremely low and therefore considered unlikely to affect the population adversely: mean blubber concentrations, expressed on an extractable basis, were 2.04 (SD = 1.1) ppm for PCBs and 2.76 (SD = 1.66) ppm for tDDT. The mean blubber retinol concentration for the overall population was 59.66 (SD = 45.26) μg g -1 . Taking into account the high contribution of blubber to body mass, blubber constitutes a significant body site for retinoid deposition in harbour porpoises. Retinol concentrations did not differ significantly between geographical regions or sexes, but they did correlate significantly (p < 0.001) with age. Body condition, measured by determining the lipid content of the blubber, did not have a significant effect on retinol levels but the individuals examined were considered to be in an overall good nutritive condition. It is concluded that measurement of retinol concentrations in blubber samples is feasible and has a potential for use as a biomarker of organochlorine exposure in cetaceans. However, in order to do so, biological information, particularly age, is critical for the correct assessment of physiological impact.
年轻和老年女性的β-胡萝卜素血清反应。
影响因子：
4.7
作者：
Maiani,G;Mobarhan,S;Ceccanti,M;Ranaldi,L;Gettner,S;Bowen,P;Friedman,H;DeLorenzo,A;Ferro-Luzzi,A
通讯作者：
Ferro-Luzzi,A