Phospholipid remodeling/generation in Giardia:: the hole of the Lands cycle
Phospholipid remodeling/generation in Giardia:: the hole of the Lands cycle
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DOI：
10.1016/s1471-4922(01)01901-8
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发表时间：
2001-07-01
影响因子：
9.6
通讯作者：
Stevens, T
中科院分区：
文献类型：
--
作者：
Das, S;Castillo, C;Stevens, T
最近的结果表明，贾第虫能够进行脱酰化/反应化反应(Lands循环)来生成新的磷脂，有效地绕过了整个磷脂分子的从头合成。这种脱酰/反应循环的成功运作对贾第鞭毛虫很重要，因为这种原生动物的脂肪合成能力有限。本文讨论了贾第鞭毛虫在人体小肠定植期间如何利用Lands循环来处理从宿主那里获得的磷脂。
Recent results suggest that Giardia is able to carry out deacylation/reacylation reactions (the Lands cycle] to generate new phospholipids, effectively bypassing the de novo synthesis of the entire phospholipid molecule. The successful operation of this deacylation/reacylation cycle is important for Giardia because this protozoan parasite possesses limited lipid synthesis ability. This article discusses how Giardia might use the Lands cycle to after phospholipids acquired from the host during its colonization in the human small intestine.