THE NEURONAL MINERALOCORTICOID RECEPTOR AS A MEDIATOR OF GLUCOCORTICOID RESPONSE
THE NEURONAL MINERALOCORTICOID RECEPTOR AS A MEDIATOR OF GLUCOCORTICOID RESPONSE
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DOI：
10.1016/0896-6273(88)90136-5
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发表时间：
1988-11-01
期刊：
影响因子：
16.2
通讯作者：
EVANS, RM
中科院分区：
文献类型：
--
作者：
ARRIZA, JL;SIMERLY, RB;EVANS, RM
盐皮质激素受体（MR）和糖皮质激素受体（CR）cDNA的克隆为了解糖皮质激素在中枢神经系统中的作用提供了基础。结构证据表明I型皮质类固醇结合位点与大脑中表达的MR相同。这种鉴定是由MR mRNA的解剖分布，原位杂交组织化学，这平行的类固醇放射自显影定位的I型网站确定的支持。MR和CR功能的体外测定表明，这些受体对不同水平的糖皮质激素有反应，这表明它们共同赋予了对该激素更大的动态敏感性范围。这些研究为糖皮质激素在中枢神经系统中的作用提出了一个新的假说。
The cloning of the mineralocorticoid receptor (MR) and the glucocorticoid receptor (CR) cDNAs provides a basis for understanding the actions of glucocorticoids in the central nervous system. Structural evidence is presented for the identity of the type I corticosteroid binding site as the MR expressed in the brain. This identification is supported by the anatomical distribution of MR mRNA, determined by in situ hybridization histochemistry, which parallels the steroid autoradiographic localization of the type I sites. An in vitro assay for MR and CR function demonstrates that these receptors respond to different levels of glucocorticoid, suggesting that together they confer a larger dynamic range of sensitivity to this hormone. These studies lead to a new hypothesis for glucocorticoid action in the central nervous system.