Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway
Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway
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DOI：
10.1016/j.devcel.2005.10.016
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发表时间：
2005-12-01
影响因子：
11.8
通讯作者：
Eaton, S
中科院分区：
文献类型：
--
作者：
Classen, AK;Anderson, KI;Eaton, S
有序细胞堆积几何结构的机制对许多组织的功能至关重要，但人们对它们的了解甚少。在这里，我们调查这个问题在发展中的果蝇翅膀。翅的表面由六边形排列的毛装饰，这些毛通过平面细胞极性途径均匀地定向。它们由六边形排列的翅膀上皮细胞构成。翅上皮细胞在大部分发育过程中排列不规则，但在毛形成前不久变成六边形。在此过程中，单个细胞边界生长和收缩，导致局部邻居交换，钙粘蛋白被积极内吞并通过Rab11内体再循环。阻碍性堆积取决于平面细胞极性蛋白的活性。我们认为这些蛋白质在连接重塑过程中抑制了含钙粘蛋白的外囊泡的运输。这可能是不同系统中平面细胞极性蛋白作用的共同机制。
The mechanisms that order cellular packing geometry are critical for the functioning of many tissues, but they are poorly understood. Here, we investigate this problem in the developing wing of Drosophila. The surface of the wing is decorated by hexagonally packed hairs that are uniformly oriented by the planar cell polarity pathway. They are constructed by a hexagonal array of wing epithelial cells. Wing epithelial cells are irregularly arranged throughout most of development, but they become hexagonally packed shortly before hair formation. During the process, individual cell boundaries grow and shrink, resulting in local neighbor exchanges, and Cadherin is actively endocytosed and recycled through Rab11 endosomes. Hexagonal packing depends on the activity of the planar cell polarity proteins. We propose that these proteins polarize trafficking of Cadherin-containing exocyst vesicles during junction remodeling. This may be a common mechanism for the action of planar cell polarity proteins in diverse systems.