AKAP phosphatase complexes in the heart.
AKAP phosphatase complexes in the heart.
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DOI：
10.1097/fjc.0b013e31821e5649
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发表时间：
2011-10
影响因子：
3
通讯作者：
Dodge-Kafka KL
中科院分区：
文献类型：
--
作者：
Redden JM;Dodge-Kafka KL
Directed protein phosphorylation is indisputably critical for a multitude of cellular processes. A growing body of research demonstrates A Kinase Anchoring Proteins (AKAPs) to mediate a significant number of phosphorylation events in the heart. By acting as molecular tethers for the regulatory subunit of PKA, AKAPs focus the kinase's actions onto specific substrates. In the time since their discovery, the AKAP model has evolved in appreciation of the broader role these scaffolds play in coordinating multiple signaling enzymes in order to efficiently regulate dynamic cellular processes. The focus of this review is on the emerging role of AKAPs in regulating the three main cardiac phosphatases: Protein Phosphatase 1 by AKAP18 and Yotiao, and Protein Phosphatases 2A and 2B by mAKAP.
