Conservation of divergent transcription in fungi
Conservation of divergent transcription in fungi
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DOI：
10.1016/j.tig.2008.02.003
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发表时间：
2008-05-01
影响因子：
11.4
通讯作者：
Huynen, Martijn A.
中科院分区：
文献类型：
--
作者：
Kensche, Philip R.;Oti, Martin;Huynen, Martijn A.
完全测序的基因组的比较使得能够研究决定基因组组织的选择性约束。我们发现，在真菌中，相邻的发散转录的 () 基因在方向上比聚合的 (->->) 基因对更保守。此外，两个基因的时间分歧方向是保守的，与它们的共表达程度以及它们功能相关的可能性相关。由保守的不同基因对编码的蛋白质的功能相互作用表明真核生物中蛋白质功能预测的潜力。
The comparison of fully sequenced genomes enables the study of selective constraints that determine genome organisation. We show that, in fungi, adjacent divergently transcribed () genes are more conserved in orientation than convergent (->->) gene pairs. Furthermore, the time divergent orientation of two genes is conserved correlates with the degree of their co-expression and with the likelihood of them being functionally related. The functional interactions of the proteins encoded by the conserved divergent gene pairs indicate a potential for protein function prediction in eukaryotes.