An expanding toolkit for preclinical pre-erythrocytic malaria vaccine development: bridging traditional mouse malaria models and human trials.
An expanding toolkit for preclinical pre-erythrocytic malaria vaccine development: bridging traditional mouse malaria models and human trials.
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DOI：
10.2217/fmb-2016-0077
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发表时间：
2016-11
影响因子：
3.1
通讯作者：
R. Steel;S. Kappe;B. Sack
中科院分区：
文献类型：
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作者：
R. Steel;S. Kappe;B. Sack
疟疾仍然是一个重大的公共卫生负担，2015年有2.14亿新感染病例，40多万人死亡。阐明相关的疟原虫寄生虫生物学可以导致确定新的方法来控制并最终消除地理区域内的寄生虫。特别地，靶向临床沉默的红细胞前感染阶段的有效疫苗的开发将通过预防血液阶段感染/疾病的发作以及寄生虫通过蚊子传播的传播来显著增强现有的疟疾消除工具。在这方面，我们讨论了小动物模型在红细胞前期疫苗开发中的作用，强调了人类肝脏嵌合体和人类免疫系统小鼠如何成为这些努力的重要组成部分。
Malaria remains a significant public health burden with 214 million new infections and over 400,000 deaths in 2015. Elucidating relevant Plasmodium parasite biology can lead to the identification of novel ways to control and ultimately eliminate the parasite within geographic areas. Particularly, the development of an effective vaccine that targets the clinically silent pre-erythrocytic stages of infection would significantly augment existing malaria elimination tools by preventing both the onset of blood-stage infection/disease as well as spread of the parasite through mosquito transmission. In this Perspective, we discuss the role of small animal models in pre-erythrocytic stage vaccine development, highlighting how human liver-chimeric and human immune system mice are emerging as valuable components of these efforts.