Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule.
Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule.
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DOI：
10.1007/s00018-015-1848-8
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Schelling JR
中科院分区：
文献类型：
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作者：
Parker MD;Myers EJ;Schelling JR
质膜Na+ -H +交换器NHE1是一种普遍表达的12跨膜蛋白，指导重要的细胞功能，如细胞内稳态体积和pH控制。NHE1的315个氨基酸胞质尾部结合质膜磷脂和多种调节额外的、与离子易位无关的功能的蛋白质。本文综述了NHE1的结构/功能关系，以及NHE1在肾近端小管功能中的作用，包括pH调节、载体Na+转运、细胞体积控制和细胞存活。这些功能的含义在进行性蛋白尿肾病的情况下尤为重要，在这种情况下，重吸收脂肪酸的积累导致nhe1膜磷脂相互作用的破坏和小管萎缩，这是进展到终末期肾病的不良预后因素。这一综述放大了近端小管NHE1 Na+ -H +交换器作为肾细胞存活因子的重要作用。
The ubiquitously expressed plasma membrane Na+–H+ exchanger NHE1 is a 12 transmembrane-spanning protein that directs important cell functions such as homeostatic intracellular volume and pH control. The 315 amino acid cytosolic tail of NHE1 binds plasma membrane phospholipids and multiple proteins that regulate additional, ion-translocation independent functions. This review focuses on NHE1 structure/function relationships, as well as the role of NHE1 in kidney proximal tubule functions, including pH regulation, vectorial Na+ transport, cell volume control and cell survival. The implications of these functions are particularly critical in the setting of progressive, albuminuric kidney diseases, where the accumulation of reabsorbed fatty acids leads to disruption of NHE1-membrane phospholipid interactions and tubular atrophy, which is a poor prognostic factor for progression to end stage renal disease. This review amplifies the vital role of the proximal tubule NHE1 Na+–H+ exchanger as a kidney cell survival factor.