MONITORING OF CONCENTRATIONS OF CLOBAZAM AND NORCLOBAZAM IN SERUM AND SALIVA OF CHILDREN WITH EPILEPSY
MONITORING OF CONCENTRATIONS OF CLOBAZAM AND NORCLOBAZAM IN SERUM AND SALIVA OF CHILDREN WITH EPILEPSY
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DOI：
10.1016/s0387-7604(12)80025-8
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发表时间：
1991-01-01
影响因子：
1.7
通讯作者：
SANTAVUORI, P
中科院分区：
文献类型：
--
作者：
BARDY, AH;SEPPALA, T;SANTAVUORI, P
氯巴唑是在90例耐药癫痫患儿原有抗癫痫药物治疗的基础上添加的。10名患者不再癫痫发作，尽管其中4人后来产生了耐受性。33名患者癫痫发作频率下降，其中24名患者也产生了耐受性。44例患者癫痫发作频率没有变化，3例发作频率增加。肌阵挛性发作患者的效果最好，而复杂部分性发作患者通常会产生耐受性。测定了251份血清和57份唾液中氯巴唑及其活性代谢物诺氯巴唑的浓度。无癫痫发作组氯巴唑和去甲氯巴唑浓度最低；耐受性与最高浓度有关。有益的副作用与低浓度的诺氯巴唑有关，而副作用与高浓度的诺氯巴唑有关。唾液氯巴唑和去甲氯巴唑浓度与血清浓度相关。监测氯巴唑和诺氯巴唑的血清和唾液浓度只有有限的价值，不能给出治疗目标范围。
Clobazam was added to the previous antiepileptic drug therapy of 90 children suffering from drug resistant epilepsy. Ten patients became seizure free, although four of these later developed tolerance. Thirty-three patients experienced a decrease in seizure frequency, and 24 of these, too, developed tolerance. Forty-four patients showed no change in seizure frequency, and three experienced an increase. The best results were experienced by patients with myoclonic seizures, whereas patients with complex partial seizures usually developed tolerance. The concentrations of clobazam and its active metabolite norclobazam were measured in 251 serum and 57 saliva samples. The group of seizure-free patients had the lowest clobazam and norclobazam concentrations; tolerance was associated with the highest concentrations. Beneficial side effects were associated with low, and adverse effects with high, concentrations of norclobazam. The concentrations of clobazam and norclobazam in saliva correlated with concentrations in serum. Monitoring of serum and salivary concentrations of clobazam and norclobazam is of limited value only, and no therapeutic target range can be given.