A realistic simulation of saccular cerebral aneurysm formation: focussing on a novel haemodynamic index, the gradient oscillatory number
A realistic simulation of saccular cerebral aneurysm formation: focussing on a novel haemodynamic index, the gradient oscillatory number
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DOI：
10.1080/10618560902953575
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发表时间：
2009-01-01
影响因子：
1.3
通讯作者：
Yamaguchi, T.
中科院分区：
文献类型：
--
作者：
Shimogonya, Y.;Ishikawa, T.;Yamaguchi, T.
尽管脑动脉瘤如何发生和生长仍不清楚，但血流动力学被认为发挥着重要作用。为了更好地了解动脉瘤形成机制，我们对患者特定动脉几何形状的动脉瘤形成进行了计算分析。首先，使用 CFD 进行脉动血流分析并计算新的血液动力学指数，即梯度振荡数 (GON)。然后，使用假设壁增殖的动脉瘤生长模型，我们基于GON指数分布进行了动脉瘤形成分析。结果表明，根据我们对患者特定动脉几何形状的假设，可能会出现囊状脑动脉瘤。另一方面，当假设壁的强度仅下降时，没有观察到囊状动脉瘤。我们的研究结果表明，动脉生物学过程，例如壁的增殖，可能在囊状动脉瘤的形成中发挥至关重要的作用。
Although how cerebral aneurysms initiate and grow is still unclear, haemodynamics is thought to play an important role. In order to better understand the aneurysm formation mechanism, we performed a computational analysis of aneurysm formation for a patient-specific arterial geometry. First, CFD was used to perform a pulsatile blood flow analysis and calculate a novel haemodynamic index, the gradient oscillatory number (GON). Then, using aneurysm growth model in which the proliferation of the wall was hypothesised, we performed an aneurysm formation analysis based on the GON index distribution. The result showed that a saccular cerebral aneurysm could appear based on our hypothesis for a patient-specific arterial geometry. On the other hand, a saccular aneurysm was not observed when assuming only strength degradation of the wall. Our findings have suggested that an arterial biological process, such as the proliferation of the wall, may play a vital role in saccular aneurysm formation.