POLIOMYELITIS INFECTION IN HOUSEHOLDS - FREQUENCY OF VIREMIA AND SPECIFIC ANTIBODY RESPONSE
POLIOMYELITIS INFECTION IN HOUSEHOLDS - FREQUENCY OF VIREMIA AND SPECIFIC ANTIBODY RESPONSE
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DOI：
10.1093/oxfordjournals.aje.a119706
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发表时间：
1954-01-01
影响因子：
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通讯作者：
PAFFENBARGER, RS
中科院分区：
文献类型：
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作者：
BODIAN, D;PAFFENBARGER, RS
1952年，在明尼苏达州奥姆斯特德县和马里兰州巴尔的摩，从132例脊髓灰质炎病例的家庭接触者中采集了血清样本，这些样本是在指示病例发病几天后和一个月后采集的。后来。从首次出血时未检出1型抗体的9例患儿中，从5例患儿的初始血清标本中分离到1型脊髓灰质炎病毒。在接下来的2到4周内，所有5名儿童的1型抗体都急剧上升，4名儿童在最初出血后的几天内出现了“流产”的脊髓灰质炎症状。在长达一个月的观察期内，33名儿童的1型抗体水平上升了至少10倍；81名儿童的1型抗体水平在每对血清中超过1：100(1：2)。在这些儿童中，没有一人表现出对2型和3型脊髓灰质炎病毒的特异性抗体升高。在成人中脊髓灰质炎很常见的奥姆斯特德县，可以研究在儿童接触者中检测到的特定抗体升高与家庭中指示病例年龄的关系。在20岁以下指示病例的接触者中检测到抗体反应的频率是与20岁以下指示病例相关的接触者的3倍。老的或老的。在84名瘫痪病例的家庭接触者中，只有6人在病例发病后的一个月内没有感染的证据，但相应的病例在家庭伙伴首次出血时显示粪便中有脊髓灰质炎病毒。两名家庭接触者分别在首次出血后1天和3天瘫痪，在首次出血时已有较高水平的1型中和抗体。
Serum specimens from 132 child household contacts of poliomyelitis cases in Olmsted County, Minnesota, and in Baltimore, Maryland, in 1952, were obtained a few days after onset of the index case, and one mo. later. Type 1 poliomyelitis virus was isolated from the initial blood serum specimen of 5 children, out of a total of 9 who had no type 1 antibody at the time of initial bleeding. All 5 children experienced a sharp rise in type 1 antibody during the following 2 to 4 wks., and 4 had symptoms of "abortive" poliomyelitis within a few days after initial bleeding. Thirty-three children had a rise in type 1 antibody of at least 10-fold in the mo.-long observation period; 81 had levels of type 1 antibody ex-ceeding 1:100 in each of the paired sera (1:2). No specific anti- body rise was demonstrated in any of these children for types 2 and 3 poliomyelitis viruses. In Olmsted County, where poliomyelitis in adults was common, it was possible to study the relation of detection of specific antibody rises in child contacts to age of the index case in the household. Antibody responses were detected 3 times as often in contacts of index cases under 20, as in those associated with index cases 20 yrs. old or older. Of 84 household contacts of paralytic cases, only 6 gave no evidence of infection during the month following onset of the case, yet the corresponding cases were shown to have poliomyelitis virus in the feces at the time of initial bleeding of the household associates. Two household contacts who became paralyzed one and 3 days after the initial bleeding, respectively, already had a high level of type 1 neutralizing antibody at the time of the first bleeding.