Sleep and the Testis.
Sleep and the Testis.
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睡眠和睾丸。
DOI：
10.1016/j.coemr.2021.03.002
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发表时间：
2021-06
影响因子：
--
通讯作者：
Liu PY
中科院分区：
文献类型：
--
作者：
O'Byrne NA;Yuen F;Niaz W;Liu PY
睡眠障碍会损害神经认知功能，现在被认为会导致代谢疾病。这篇综述评估了睡眠不足、失调和紊乱与男科健康之间的新生关系。高质量的队列研究表明，睡眠障碍的男性精子数量减少。精心设计的干预研究表明，睡眠限制会降低睾酮水平。对长期轮班工人的研究表明，睡眠失调对平均睾酮浓度没有影响。患有阻塞性睡眠呼吸暂停（OSA）和更严重的低氧血症的男性睾酮水平较低，尽管尚不清楚这种关系是否完全由伴随的肥胖来解释，或者是可逆的。然而，OSA 男性常见的勃起功能障碍在 OSA 得到适当治疗后在临床上得到改善。在老年男性中进行的控制睡眠的研究很少，在这些男性中，数十年来睡眠障碍的积累可能会导致与年龄相关的疾病。改善睡眠可以改善这些疾病的发展。
Disordered sleep impairs neurocognitive performance, and is now recognized to cause metabolic ill-health. This review assesses the nascent relationship between insufficient, misaligned, and disrupted sleep with andrological health. High-quality cohort studies show a reduced sperm count in men with sleep disturbances. Well-designed interventional studies show a reduction in testosterone with sleep restriction. Studies of long-term shift workers show no effect of misaligned sleep on mean testosterone concentrations. Men with obstructive sleep apnea (OSA) and more severe hypoxemia have lower testosterone levels, although it is unknown if this relationship is entirely explained by concomitant obesity, or is reversible. Nevertheless, erectile dysfunction, which is common in men with OSA, is clinically improved when OSA is properly treated. Few studies manipulating sleep have been performed in older men, in whom the accumulation of sleep disturbances over decades of life may contribute to age-related illnesses. Improving sleep could ameliorate the development of these disorders.