POTENTIAL APPLICATIONS OF FT-RAMAN SPECTROSCOPY FOR DERMATOLOGICAL DIAGNOSTICS
POTENTIAL APPLICATIONS OF FT-RAMAN SPECTROSCOPY FOR DERMATOLOGICAL DIAGNOSTICS
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DOI：
10.1016/0022-2860(95)08560-i
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发表时间：
1995-03-01
影响因子：
3.8
通讯作者：
BARRY, BW
中科院分区：
文献类型：
--
作者：
EDWARDS, HGM;WILLIAMS, AC;BARRY, BW
拉曼光谱已经从正常、健康的人角质层、愈伤组织和角化过度的银屑病斑块获得。已经对光谱进行了分析，在1000-1500和2800-3100 cm（-1）波数区域的变化与异常组织中的脂质损失有关，但角蛋白成分在结构上没有改变。评估了FT-拉曼光谱技术用于诊断人体组织中角化过度状况的潜力。
Raman spectra have been obtained from normal, healthy human stratum corneum, callus tissue and hyperkeratotic psoriatic plaques. Assignments of the spectra have been made and changes in the 1000-1500 and 2800-3100 cm(-1) wavenumber regions have been related to lipid loss in the abnormal tissues but the keratin component is structurally unaltered. The potential of the FT-Raman spectroscopic technique for diagnosis of hyperkeratotic conditions in human tissue is assessed.