Gluten intake and risk of psoriasis, psoriatic arthritis, and atopic dermatitis among United States women
Gluten intake and risk of psoriasis, psoriatic arthritis, and atopic dermatitis among United States women
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DOI：
10.1016/j.jaad.2019.08.007
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发表时间：
2020-03-01
影响因子：
13.8
通讯作者：
Cho, Eunyoung
中科院分区：
文献类型：
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作者：
Drucker, Aaron M.;Qureshi, Abrar A.;Cho, Eunyoung
背景资料：麸质摄入量和银屑病，银屑病关节炎，和特应性dermatitis之间的关联知之甚少。Objective：为了确定是否增加麸质摄入量与银屑病，银屑病关节炎，和特应性dermatitis.Methods：护士健康研究II中的妇女队列研究。每4年（1991-2015年为银屑病疾病，1995-2013年为特应性皮炎）使用食物频率问卷来计算参与者饮食中的麸质含量。通过自我报告评估疾病结局，随后进行验证。多变量调整考克斯比例风险模型被用来计算风险比和95%置信区间之间的关联面筋摄入量（五分位数）和银屑病，银屑病关节炎，特应性dermatitis.Results：我们包括85，185参与银屑病分析，85，324在银屑病关节炎分析，和63，443在特应性皮炎分析。谷蛋白摄入量增加与任何结果无关（所有P趋势> 0.05）。比较最高和最低谷蛋白摄入量的五分位数，（95%置信区间）为1.15（0.98-1.36）银屑病，1.12银屑病关节炎0.78-1.62，（0.66-1.25）对于特应性皮炎。局限性：没有评估严格的无麸质饮食。结论：我们的研究结果不支持饮食中谷蛋白的摄入量是成年女性银屑病、银屑病关节炎或特应性皮炎的危险因素。
Background: Associations between gluten intake and psoriasis, psoriatic arthritis, and atopic dermatitis are poorly understood.Objective: To determine whether increased gluten intake is associated with incident psoriasis, psoriatic arthritis, and atopic dermatitis.Methods: Cohort studies among women in Nurses' Health Study II. Food frequency questionnaires were used to calculate gluten content of participants' diet every 4 years (1991-2015 for psoriatic disease, 1995-2013 for atopic dermatitis). Disease outcomes were assessed by self-report and subsequently validated. Multivariable-adjusted Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for the association between gluten intake (quintiles) and psoriasis, psoriatic arthritis, and atopic dermatitis.Results: We included 85,185 participants in the psoriasis analysis, 85,324 in the psoriatic arthritis analysis, and 63,443 in the atopic dermatitis analysis. Increased gluten intake was not associated with any of the outcomes (all P for trend >.05). Comparing highest and lowest gluten intake quintiles, the multivariable hazard ratios (95% confidence intervals) were 1.15 (0.98-1.36) for psoriasis, 1.12 (0.78-1.62) for psoriatic arthritis, and 0.91 (0.66-1.25) for atopic dermatitis.Limitations: No assessment of a strictly gluten-free diet.Conclusions: Our findings do not support the amount of dietary gluten intake as a risk factor for psoriasis, psoriatic arthritis, or atopic dermatitis in adult women.