Comparison of conjunctival staining between lissamine green and yellow filtered fluorescein sodium
Comparison of conjunctival staining between lissamine green and yellow filtered fluorescein sodium
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DOI：
10.1016/j.jcjo.2015.05.007
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发表时间：
2015-08-01
影响因子：
4.2
通讯作者：
Song, Jong Suk
中科院分区：
文献类型：
--
作者：
Eom, Youngsub;Lee, Jong-Suk;Song, Jong Suk
目的：使用黄色屏障滤光器比较丽丝胺绿和荧光素钠的结膜染色。设计：回顾性横断面研究。参与者：13 名干眼患者的 13 只眼睛。方法：所有患者均接受荧光素钠和丽丝胺绿的眼表染色。在钴蓝色照明和黄色滤光片下通过裂隙灯检查观察荧光素钠的眼表面染色。根据牛津方案分别对颞部（0-5）和鼻部（0-5）结膜染色等级进行分级。对比度分数定义为点状染色和背景的平均灰度值之间的绝对差。比较这2种染色方法的结膜染色等级和对比度评分。结果：荧光素钠鼻结膜和颞结膜的结膜染色等级（0-10）之和为4.7 +/- 2.5，显着高于丽丝胺绿的4.1 +/- 2.5（p = 0.005）。荧光素钠的颞部和鼻结膜染色对比评分分别为 34.6 +/- 12.0 和 34.7 +/- 10.3，也显着高于丽丝胺绿（分别为 23.4 +/- 8.1 和 21.0 +/- 9.0；分别为 p = 0.003 和 p = 0.003）。结论：使用荧光素钠和黄色滤光片进行结膜染色似乎比丽丝胺绿对结膜损伤的检测更敏感。使用黄色滤光片进行荧光素染色的优点是可以同时观察干眼患者的角膜和结膜损伤，而无需额外的活体染色。
Objective: To compare conjunctival staining between lissamine green and fluorescein sodium using a yellow barrier filter.Design: Retrospective cross-sectional study.Participants: Thirteen eyes of 13 patients with dry eyes.Methods: All patients underwent ocular surface staining with fluorescein sodium and lissamine green. Ocular surface staining with fluorescein sodium was observed through slit-lamp examination under cobalt blue illumination and a yellow filter. Temporal (0-5) and nasal (0-5) conjunctival staining grade was separately graded according to the Oxford scheme. The contrast score was defined as the absolute difference between mean grey values of punctate staining and background. Conjunctival staining grade and contrast scores were compared between these 2 staining methods.Results: The sum of the conjunctival staining grade (0-10) for the nasal and temporal conjunctiva was 4.7 +/- 2.5 for fluorescein sodium, which was significantly higher than that of lissamine green, 4.1 +/- 2.5 (p = 0.005). The contrast score of temporal and nasal conjunctival staining was 34.6 +/- 12.0 and 34.7 +/- 10.3, respectively, for fluorescein sodium, which was also significantly greater than for lissamine green (23.4 +/- 8.1 and 21.0 +/- 9.0, respectively; p = 0.003 and p = 0.003, respectively).Conclusions: Conjunctival staining with fluorescein sodium and a yellow filter seems to be more sensitive for the detection of conjunctival damage than lissamine green. Fluorescein staining with the yellow filter has the advantage of simultaneous observation of both corneal and conjunctival damage in patients with dry eye without the need for additional vital staining.