Central and peripheral circadian oscillator mechanisms in flies and mammals.
Central and peripheral circadian oscillator mechanisms in flies and mammals.
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发表时间：
2002-09
影响因子：
4
通讯作者：
N. Glossop;P. Hardin
中科院分区：
文献类型：
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作者：
N. Glossop;P. Hardin
昼夜节律振荡器是细胞自主计时机制，存在于许多生物体的各种组织中。在果蝇和小鼠中，维持这些振荡的核心分子成分是高度保守的，但其中一些成分的功能似乎已经显著分化。产生这些差异的一个可能原因是，之前的比较主要集中在小鼠的中心振荡器和果蝇的外围振荡器上。最近对小鼠和果蝇外周振荡器的研究表明，这些生物之间的核心元件的功能可能比最初认为的更加高度保守，这表明：(1)果蝇的中央振荡器和外周振荡器不一定具有相同的分子机制；(2)哺乳动物中枢振荡器与外周振荡器的调节方式不同；(3)物种内部和物种间不同的外围振荡具有惊人的相似性。因此，外围振荡器中的核心反馈回路可能在功能上很好地保守，而中心振荡器可能是基本振荡器设计的专门版本。
Circadian oscillators are cell-autonomous time-keeping mechanisms that reside in diverse tissues in many organisms. In flies and mice, the core molecular components that sustain these oscillators are highly conserved, but the functions of some of these components appear to have diverged significantly. One possible reason for these differences is that previous comparisons have focused primarily on the central oscillator of the mouse and peripheral oscillators in flies. Recent research on mouse and Drosophila peripheral oscillators shows that the function of the core components between these organisms may be more highly conserved than was first believed, indicating the following: (1) that central and peripheral oscillators in flies do not necessarily have the same molecular mechanisms; (2) that mammalian central oscillators are regulated differently from peripheral oscillators; and (3) that different peripheral oscillators within and across species show striking similarities. The core feedback loop in peripheral oscillators might therefore be functionally well conserved, and central oscillators could be specialized versions of a basic oscillator design.