REGIONAL REWARD DIFFERENCES WITHIN THE VENTRAL PALLIDUM ARE REVEALED BY MICROINJECTIONS OF A MU-OPIATE RECEPTOR AGONIST
REGIONAL REWARD DIFFERENCES WITHIN THE VENTRAL PALLIDUM ARE REVEALED BY MICROINJECTIONS OF A MU-OPIATE RECEPTOR AGONIST
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DOI：
10.1016/0028-3908(93)90025-x
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发表时间：
1993-12-01
影响因子：
4.7
通讯作者：
PAUL, AD
中科院分区：
文献类型：
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作者：
JOHNSON, PI;STELLAR, JR;PAUL, AD
腹侧苍白球接受来自中脑边缘核的主要投射，中脑边缘核是中脑边缘多巴胺系统的一个被大量研究的终点，已知它参与各种奖励和行为功能。最近，腹侧苍白球微量注射μ阿片受体激动剂Tyr-D-Ala-Gly-NMe-Phe-Gly-ol-enkephalin（DAMGO）已显示增加运动活动，而腹侧苍白球损伤已显示减少阿片和可卡因自我给药行为。这些结果表明，可能延续的中脑边缘奖励/运动电路从丘脑腹侧苍白球核。本研究探讨腹侧苍白球DAMGO微量注射对奖励和运动/性能通过使用颅内自我刺激率频率曲线移位范例的影响。以随机剂量顺序双侧施用DAMGO（媒介物、0.03 nmol和0.33 nmol）的微量注射，注射之间至少间隔3天。在阿片类药物微量注射后立即对大鼠进行三次连续的频率-频率曲线测试，以研究药物作用的时间过程。与正常基线活动或载体微量注射相比，在喙腹侧苍白球中DAMGO微量注射产生奖励和运动/性能降低。相反，DAMGO微量注射到尾侧腹侧苍白球产生奖励和运动/性能的增加。这些数据证实了腹侧苍白球在边缘系统功能中的作用，并将其扩展到颅内自我刺激奖励。他们还建议奖励调制腹侧苍白球是一个区域异质性的功能，吻侧腹侧苍白球可能是一个过渡区之间的核腹侧苍白球。
The ventral pallidum receives a major projection from the nucleus accumbens, a heavily studied terminus of the mesolimbic dopamine system that is known to be involved in a variety of reward and behavioral functions. Recently, ventral pallidum microinjections of the mu opiate receptor agonist Tyr-D-Ala-Gly-NMe-Phe-Gly-ol-enkephalin (DAMGO) have been shown to increase motor activity while ventral pallidum lesions have been shown to reduce opiate and cocaine self-administration behaviors. These results suggest a possible continuation of the mesolimbic reward/motor circuit from the nucleus accumbens into the ventral pallidum. This study investigated the effects of ventral pallidum DAMGO microinjections on reward and motor/performance through the use of the intracranial self-stimulation rate-frequency curve-shift paradigm. Microinjections of DAMGO (vehicle, 0.03 nmol, and 0.33 nmol) were administered bilaterally in a random dose order with a minimum of 3 days between injections.: Rats were tested over three consecutive rate-frequency curves immediately following the opiate microinjections to investigate the time course of drug effects. DAMGO microinjections in the rostral ventral pallidum produced decreases in reward and motor/performance when compared to normal baseline activity or vehicle microinjections. In contrast, DAMGO microinjections into the caudal ventral pallidum produced increases in reward and motor/performance. These data confirm a role for the ventral pallidum in limbic function and extend it to intracranial self-stimulation reward. They also suggest reward modulation in the ventral pallidum is a regionally heterogeneous function and that the rostral ventral pallidum may be a transition area between the nucleus accumbens and the ventral pallidum.