EFFECT OF SESAME OIL AGAINST ACETAMINOPHEN-INDUCED ACUTE OXIDATIVE HEPATIC DAMAGE IN RATS
EFFECT OF SESAME OIL AGAINST ACETAMINOPHEN-INDUCED ACUTE OXIDATIVE HEPATIC DAMAGE IN RATS
复制标题
芝麻油对乙酰氨基酚所致大鼠急性氧化性肝损伤的作用
DOI：
10.1097/shk.0b013e318160dd6b
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发表时间：
2007
期刊：
影响因子：
3.1
通讯作者：
Ming‐Yie Liu
中科院分区：
文献类型：
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作者：
V. Chandrasekaran;C. Wan;Li;D. Hsu;Ming‐Yie Liu
对乙酰氨基酚（APAP）过量会导致人类和实验动物的急性肝损伤甚至死亡。我们研究了芝麻油对APAP诱导的急性肝损伤的影响。雄性Wistar大鼠给予APAP（1，000 mg/kg;口服）以诱导急性肝损伤。对乙酰氨基酚显着增加天冬氨酸转氨酶，丙氨酸转氨酶，脂质过氧化反应，超氧阴离子和羟基自由基的产生水平，它也诱导谷胱甘肽耗尽。芝麻油（8 mL/kg;口服）不改变APAP的胃吸收，但能抑制APAP引起的所有参数的改变，对APAP引起的大鼠急性肝损伤有保护作用。我们推测，芝麻油维持细胞内谷胱甘肽水平，降低活性氧水平，并抑制APAP诱导的急性肝损伤大鼠的脂质过氧化反应。
Acetaminophen (APAP) overdose causes acute liver injury or even death in both humans and experimental animals. We investigated the effect of sesame oil on APAP-induced acute liver injury. Male Wistar rats were given APAP (1,000 mg/kg; orally) to induce acute liver injury. Acetaminophen significantly increased aspartate transaminase, alanine transaminase, lipid peroxidation, and superoxide anion and hydroxyl radical generation levels; it also induced glutathione depletion. Sesame oil (8 mL/kg; orally) did not alter the gastric absorption of APAP, but it inhibited all the parameters altered by APAP and protected the rats against APAP-induced acute liver injury. We hypothesize that sesame oil maintained the intracellular glutathione levels, reduced reactive oxygen species levels, and inhibited lipid peroxidation in rats with APAP-induced acute liver injury.
影响因子：
3.9
作者：
Kessler, FK;Kessler, MR;Ritter, JK
通讯作者：
Ritter, JK
DOI：
10.1073/pnas.81.5.1327
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DAHLIN, DC;MIWA, GT;NELSON, SD
通讯作者：
NELSON, SD