Reactive oxygen species and redox-regulation of skeletal muscle adaptations to exercise
Reactive oxygen species and redox-regulation of skeletal muscle adaptations to exercise
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DOI：
10.1098/rstb.2005.1773
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发表时间：
2005-12-29
影响因子：
6.3
通讯作者：
Jackson, MJ
中科院分区：
文献类型：
--
作者：
Jackson, MJ
骨骼肌已被证明在休息和收缩活动期间产生一组复杂的活性氧和氮物质（ROS）。产生的主要ROS是超氧化物和一氧化氮，它们产生的模式和幅度受收缩活动性质的影响。越来越清楚的是，骨骼肌产生的ROS在影响氧化还原调节过程中起着重要作用，该过程至少控制对收缩活动的一些适应性反应。这些过程也被认为是在衰老过程中修改，并在某些疾病状态下，提供的潜力，影响ROS活性的干预措施可能会影响肌肉功能或活力，在这些情况下。
Skeletal muscle has been shown to generate a complex set of reactive oxygen and nitrogen species (ROS) both at rest and during contractile activity. The primary ROS generated are superoxide and nitric oxide and the pattern and magnitude of their generation is influenced by the nature of the contractile activity. It is increasingly clear that the ROS generated by skeletal muscle play an important role in influencing redox-regulated processes that control, at least some of, the adaptive responses to contractile activity. These processes are also recognized to be modified during ageing and in some disease states, providing the potential that interventions affecting ROS activity may influence muscle function or viability in these situations.