Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort.
Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort.
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DOI：
10.1007/s13665-012-0025-x
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发表时间：
2012-12
期刊：
影响因子：
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通讯作者：
TENOR Study Group
中科院分区：
文献类型：
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作者：
Chipps BE;Zeiger RS;Dorenbaum A;Borish L;Wenzel SE;Miller DP;Hayden ML;Bleecker ER;Simons FE;Szefler SJ;Weiss ST;Haselkorn T;TENOR Study Group
重度或难治性哮喘患者尽管仅占总哮喘人群的一小部分，但其哮喘发病率、死亡率和医疗保健负担却很大。TENOR是一项多中心、观察性、前瞻性队列研究，于2001年启动。该研究招募了4，756名患有严重或难以治疗的哮喘的成人，青少年和儿童，他们每半年和每年随访一次，持续三年，从而能够深入了解这一未充分研究的人群。在随访期间完成了广泛的人口统计学、临床和患者自我报告评估。在这里，我们介绍了TENOR登记研究中与哮喘控制和急性发作相关的关键发现，包括发现特别高风险的特定亚组的识别。识别与哮喘控制不良和加重风险增加相关的因素和亚组可以帮助医生设计个体哮喘管理，并改善这些患者的哮喘相关健康结局。
Patients with severe or difficult-to-treat asthma account for substantial asthma morbidity, mortality, and healthcare burden despite comprising only a small proportion of the total asthma population. TENOR, a multicenter, observational, prospective cohort study was initiated in 2001. It enrolled 4,756 adults, adolescents and children with severe or difficult-to-treat asthma who were followed semi-annually and annually for three years, enabling insight to be gained into this understudied population. A broad range of demographic, clinical, and patient self-reported assessments were completed during the follow-up period. Here, we present key findings from the TENOR registry in relation to asthma control and exacerbations, including the identification of specific subgroups found to be at particularly high-risk. Identification of the factors and subgroups associated with poor asthma control and increased risk of exacerbations can help physicians design individual asthma management, and improve asthma-related health outcomes for these patients.