Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences.
Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences.
复制标题
DOI：
10.1016/j.jacc.2016.11.069
复制
发表时间：
2017-02-21
影响因子：
24
通讯作者：
Somers VK
中科院分区：
文献类型：
--
作者：
Javaheri S;Barbe F;Campos-Rodriguez F;Dempsey JA;Khayat R;Javaheri S;Malhotra A;Martinez-Garcia MA;Mehra R;Pack AI;Polotsky VY;Redline S;Somers VK
睡眠呼吸暂停在心血管疾病患者中非常普遍。这些呼吸紊乱事件与一系列扰动相关，包括间歇性缺氧、氧化应激、交感神经激活和内皮功能障碍，所有这些都是心血管疾病的重要介质。有证据支持睡眠呼吸暂停与高血压、冠心病、心律失常、心力衰竭和中风的发病率和发病率有因果关系。近年来，在睡眠呼吸暂停的发病机制方面有了一些发现，同时在治疗睡眠呼吸暂停方面也取得了进展。在这篇综述中，我们讨论了睡眠呼吸暂停的机制，解决睡眠呼吸暂停和心血管疾病之间联系的证据，以及解决睡眠呼吸暂停治疗对心血管疾病和临床终点影响的研究。最后，我们回顾了睡眠呼吸暂停治疗方案的最新进展，特别考虑了治疗心脏病患者。并提出了未来的发展方向。
Sleep apnea is highly prevalent in patients with cardiovascular disease. These disordered breathing events are associated with a profile of perturbations that include intermittent hypoxia, oxidative stress, sympathetic activation, and endothelial dysfunction, all of which are critical mediators of cardiovascular disease. Evidence supports a causal association of sleep apnea with the incidence and morbidity of hypertension, coronary heart disease, arrhythmia, heart failure, and stroke. Several discoveries in the pathogenesis, along with developments in the treatment of sleep apnea, have accumulated in recent years. In this review, we discuss the mechanisms of sleep apnea, the evidence that addresses the links between sleep apnea and cardiovascular disease, and research that has addressed the effect of sleep apnea treatment on cardiovascular disease and clinical endpoints. Finally, we review the recent development in sleep apnea treatment options, with special consideration of treating patients with heart disease. Future directions for selective areas are suggested.