White matter changes in late-life depression: A diffusion tensor imaging study
White matter changes in late-life depression: A diffusion tensor imaging study
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DOI：
10.1016/j.jad.2011.07.025
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发表时间：
2011-12-01
影响因子：
6.6
通讯作者：
O'Brien, John T.
中科院分区：
文献类型：
--
作者：
Colloby, Sean J.;Firbank, Michael J.;O'Brien, John T.
背景：大量研究表明，老年抑郁症（LLD）患者存在白色物质异常。目的是调查白色物质束的完整性与LLD的主题相比，类似的年龄健康人使用扩散张量成像（DTI）。方法：68名受试者（30名健康人，38名抑郁症）进行了DTI的3 T扫描仪的临床和认知评估。使用自动化的基于轨迹的空间统计（TBSS）方法来获得每个受试者的各向异性分数（FA）和平均扩散率（MD）的估计值。结果：与对照组相比，未校正的DTI图显示LLD患者的额叶、颞叶和中脑区FA较低（P <0.05），与对照组相比，LLD患者的额叶、颞叶和中脑区FA较低（P <0.05）。
Background: Numerous studies have revealed white matter abnormalities in late-life depression (LLD). The objective was to investigate the integrity of white matter tracts in subjects with LLD compared to similar aged healthy individuals using diffusion tensor imaging (DTI).Methods: Sixty eight subjects (30 healthy individuals, 38 depressed) underwent DTI on a 3 T scanner following clinical and cognitive assessment. An automated tract-based spatial statistics (TBSS) method was used to derive estimates of fractional anisotropy (FA) and mean diffusivity (MD) for each subject. Group effects and correlations with clinical features on DTI parameters were examined.Results: Compared to controls, uncorrected maps revealed patients with LLD exhibited lower FA in frontal, temporal and midbrain regions relative to older healthy subjects (p