High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese - The Hisayama study
High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese - The Hisayama study
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DOI：
10.1161/atvbaha.107.157164
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发表时间：
2008-07-01
影响因子：
8.7
通讯作者：
Kiyohara, Yutaka
中科院分区：
文献类型：
--
作者：
Arima, Hisatomi;Kubo, Michiaki;Kiyohara, Yutaka
目的：本研究旨在探讨超敏C反应蛋白(hs-CRP)在日本普通人群中对冠心病(CHD)风险的影响。方法与结果：Hisayama研究是一项基于人群的前瞻性队列研究。共有2589名年龄在40岁或以上的参与者接受了长达14年的跟踪调查。结果是发生冠心病(心肌梗死、冠状动脉血运重建和心脏性猝死)。基线时超敏C反应蛋白水平中位数为0.43 mg/L。在随访期内，观察到129个冠状动脉事件。年龄和性别调整后的冠心病年发病率随着hs-CRP值的升高而递增：hs-CRP1.02 mg/L定义的四分位数组分别为1.6、3.3、4.5和7.4/1000人年(P1.0 mg/L)，远低于西方人群。
Objective-The purpose of this study was to investigate the effects of high-sensitivity C-reactive protein (hs-CRP) on the risks of coronary heart disease (CHD) in a general population of Japanese.Methods and Results-The Hisayama study is a population-based prospective cohort study. A total of 2589 participants aged 40 years or older were followed up for 14 years. Outcomes are incident CHD (myocardial infarction, coronary revascularization, and sudden cardiac death). The median hs-CRP level was 0.43 mg/L at baseline. During the follow-up period, 129 coronary events were observed. Age- and sex-adjusted annual incidence rates of CHD rose progressively with higher hs-CRP levels: 1.6, 3.3, 4.5, and 7.4 per 1000 person-years for quartile groups defined by hs-CRP levels of 1.02 mg/L, respectively (P1.0 mg/L, which is much lower than that for Western populations.