Critical assessment of the efficiency of chitosan biohydrogel beads as recyclable and heterogeneous organocatalyst for C-C bond formation
Critical assessment of the efficiency of chitosan biohydrogel beads as recyclable and heterogeneous organocatalyst for C-C bond formation
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DOI：
10.1039/c1gc15925a
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发表时间：
2012-01-01
期刊：
影响因子：
9.8
通讯作者：
Diaz Diaz, David
中科院分区：
文献类型：
--
作者：
Kuehbeck, Dennis;Saidulu, G.;Diaz Diaz, David
对中性pH壳聚糖水凝胶珠（CSHB）作为多种C-C键形成反应（即醛醇反应、Knoevenagel缩合反应、硝基醛醇（Henry）反应、Michael加成反应）的绿色有机催化剂的有效性进行了综合评价。研究了反应速率、转化率和选择性作为一系列输入变量的函数，这些变量包括微球的尺寸、pH和反应表面积、催化剂负载、温度、生物聚合物的分子量、浓度、溶剂体系和反应物的摩尔比。此外，通过SEM、FT-IR、TGA和DSC等多种技术对催化生物水凝胶珠进行了表征。
The effectiveness of neutral pH chitosan hydrogel beads (CSHB) as a green organocatalyst for a variety of C-C bond forming reactions (i.e. aldol reaction, Knoevenagel condensation, nitroaldol (Henry) reaction, Michael addition) has been comprehensively evaluated. Reaction rates, conversions and selectivities were studied as a function of a series of input variables including size, pH and reactive surface area of the beads, catalyst loading, temperature, molecular weight of the biopolymer, concentration, solvent system and molar ratio of reactants. Moreover, the catalytic biohydrogel beads were characterized by a variety of techniques including, among others, SEM, FT-IR, TGA and DSC.