Serum microRNAs as potential biomarkers of mandibular prognathism
Serum microRNAs as potential biomarkers of mandibular prognathism
复制标题
血清 microRNA 作为下颌前突的潜在生物标志物
DOI：
10.1111/odi.12073
复制
发表时间：
2014-01-01
期刊：
影响因子：
3.8
通讯作者：
Wang, L.
中科院分区：
文献类型：
--
作者：
Gu, Y.;Zhang, Y.;Wang, L.
目的：本研究的目的是确定特定的循环血清microRNAs（miRNAs）的表达水平是否与下颌骨多颌畸形（MP）相关。68名恒牙列早期的正常对照者和24名替牙列期的正常对照者被招募用于比较。结果在MP组中，let-7i-3 p在永久性骨髓增生异常综合征早期明显过表达（P < 0. 05），而在正常对照组中，let-7i-3 p在永久性骨髓增生异常综合征早期明显过表达（P < 0. 05）。
Objectives: The aim of the study was to determine whether the expression levels of specific circulating serum microRNAs (miRNAs) are associated with mandibular prognathism (MP).MethodsSixty subjects in the early permanent dentition stage and 23 in the mixed dentition stage with MP were identified. Sixty-eight normal control subjects in the early permanent dentition stage and 24 in the mixed dentition stage were recruited for comparison. According to the microarray-based expression profiling, four serum miRNAs (let-7i-3p, miR-595, miR-16-2-3p, and miR-367-5p) were validated.ResultsIn the MP groups, let-7i-3p was significantly over-expressed in subjects in the early permanent (P