Ribosome as a Translocase and Helicase.
Ribosome as a Translocase and Helicase.
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DOI：
10.1134/s0006297921080095
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Ermolenko DN
中科院分区：
文献类型：
--
作者：
Bao C;Ermolenko DN
During protein synthesis, ribosome moves along mRNA to decode one codon after the other. Ribosome translocation is induced by a universally conserved protein, elongation factor G (EF-G) in bacteria and elongation factor 2 (EF-2) in eukaryotes. EF-G-induced translocation results in unwinding of the intramolecular secondary structures of mRNA by three base pairs at a time that renders the translating ribosome a processive helicase. Professor Alexander Sergeevich Spirin has made numerous seminal contributions to understanding the molecular mechanism of translocation. Here, we review Spirin’s insights into the ribosomal translocation and recent advances in the field that stemmed from Spirin’s pioneering work. We also discuss key remaining challenges in studies of translocase and helicase activities of the ribosome.
DOI：
10.1016/0167-4781(90)90151-q
发表时间：
1990-08-27
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Balakin A;Skripkin E;Shatsky I;Bogdanov A
通讯作者：
Bogdanov A