Preparation and performance of protein-adsorption-resistant asymmetric porous membrane composed of polysulfone/phospholipid polymer blend
Preparation and performance of protein-adsorption-resistant asymmetric porous membrane composed of polysulfone/phospholipid polymer blend
复制标题
DOI：
10.1016/s0142-9612(00)00180-0
复制
发表时间：
2001-02-01
期刊：
影响因子：
14
通讯作者：
Ishihara, K
中科院分区：
文献类型：
--
作者：
Hasegawa, T;Iwasaki, Y;Ishihara, K
为了获得抗蛋白质吸附的血液透析膜，我们制备了由聚砜和2-甲基丙烯酰氧乙基磷酰胆碱（MPC）聚合物组成的聚合物共混物（PSf/MPC聚合物）。MPC聚合物在PSf中的含量为7重量%和15重量%。通过干/湿膜处理方法获得非对称多孔膜。通过X射线光电子能谱对PSf/MPC聚合物膜的表面进行表征，发现MPC聚合物位于膜的表面。与PSf膜相比，PSf/MPC聚合物膜的机械强度没有改变。另一方面，分子量（Mw）低于2.0 × 10（4）的溶质通过PSf膜的渗透性随着MPC聚合物的添加而增加，这被认为是MPC聚合物的亲水特性的影响。通过添加MPC聚合物，从血浆中吸附在PSf膜上的蛋白质的量减少。即使在PSf/MPC聚合物膜与血浆蛋白溶液接触4小时后，低分子量蛋白（Mw = 1.2 × 10（4））的渗透性也没有改变，而在PSf膜的情况下，其显著降低。血小板粘附在PSf/MPC聚合物膜上也被有效抑制。基于这些结果，MPC聚合物可以用作双功能聚合物添加剂，即，产生抗蛋白质吸附特性并使膜亲水。(C)2000爱思唯尔科技有限公司版权所有。
To obtain protein-adsorption-resistant membrane for hemodialysis, we prepared a polymer blend composed of polysulfone and 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer (PSf/MPC polymer). The content of the MPC polymer in the PSf was 7 and 15 wt%. The asymmetric porous membrane was obtained by the dry/wet membrane processing method. The surface characterization of the PSf/MPC polymer membrane by X-ray photoelectron spectroscopy revealed that the MPC polymer located at the surface. The mechanical strength of the PSf/MPC polymer membrane did not change compared with that of the PSf membrane. On the other hand, the permeability of solute below a molecular weight (Mw) of 2.0 x 10(4) through the PSf membrane increased with the addition of the MPC polymer, which is considered to be an effect of the hydrophilic character of the MPC polymer. The amount of protein adsorbed on the PSf membrane from plasma was reduced by the addition of the MPC polymer. The permeability of low-molecular-weight protein (Mw = 1.2 x 10(4)) did not change even after the PSf/MPC polymer membrane was contacted with plasma protein solution for 4 h, whereas it decreased dramatically in the case of the PSf membrane. Platelet adhesion was also effectively suppressed on the PSf/MPC polymer membrane. Based on these results, the MPC polymer could serve as a doubly functional polymeric additive, that is, to generate a protein-adsorption-resistant characteristic and to render the membrane hydrophilic. (C) 2000 Elsevier Science Ltd. All rights reserved.