Decreased Plasma Histidine Level Predicts Risk of Relapse in Patients with Ulcerative Colitis in Remission.
Decreased Plasma Histidine Level Predicts Risk of Relapse in Patients with Ulcerative Colitis in Remission.
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DOI：
10.1371/journal.pone.0140716
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kanai T
中科院分区：
文献类型：
--
作者：
Hisamatsu T;Ono N;Imaizumi A;Mori M;Suzuki H;Uo M;Hashimoto M;Naganuma M;Matsuoka K;Mizuno S;Kitazume MT;Yajima T;Ogata H;Iwao Y;Hibi T;Kanai T
溃疡性结肠炎(UC)以慢性肠道炎症为特征。UC患者反复缓解和复发。可以预测UC缓解期患者复发的临床生物标志物尚未确定。为了便于预测UC的复发，我们利用血浆游离氨基酸(PFAA)浓度的统计模型来研究新的多变量指标的潜力。我们测量了369名临床缓解期UC患者的空腹PFAA浓度，并对355名患者进行了长达一年的前瞻性观察。1年内复发率为23%(82/355)。年龄和性别调整后，血浆组氨酸浓度最低四分位数与最高四分位数的风险比为2.55(95%可信区间：1.41-4.62；p=0.0020(对数等级)，趋势p=0.0005)。我们证明，临床缓解期UC患者的血浆氨基酸谱可以预测1年内复发的风险。PFAA中组氨酸水平降低与复发风险增加相关。代谢组学有望建立炎症性肠病的无创预测标记物。
Ulcerative colitis (UC) is characterized by chronic intestinal inflammation. Patients with UC have repeated remission and relapse. Clinical biomarkers that can predict relapse in UC patients in remission have not been identified. To facilitate the prediction of relapse of UC, we investigated the potential of novel multivariate indexes using statistical modeling of plasma free amino acid (PFAA) concentrations. We measured fasting PFAA concentrations in 369 UC patients in clinical remission, and 355 were observed prospectively for up to 1 year. Relapse rate within 1 year was 23% (82 of 355 patients). The age- and gender-adjusted hazard ratio for the lowest quartile compared with the highest quartile of plasma histidine concentration was 2.55 (95% confidence interval: 1.41–4.62; p = 0.0020 (log-rank), p for trend = 0.0005). We demonstrated that plasma amino acid profiles in UC patients in clinical remission can predict the risk of relapse within 1 year. Decreased histidine level in PFAAs was associated with increased risk of relapse. Metabolomics could be promising for the establishment of a non-invasive predictive marker in inflammatory bowel disease.