Recent Developments in the Synthesis of Bioactive 2,4,6-Trisubstituted 1,3,5-Triazines
Recent Developments in the Synthesis of Bioactive 2,4,6-Trisubstituted 1,3,5-Triazines
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DOI：
10.1055/s-0033-1339284
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发表时间：
2013-08-01
期刊：
影响因子：
2
通讯作者：
Weerapana, Eranthie
中科院分区：
文献类型：
--
作者：
Banerjee, Ranjan;Brown, Douglas R.;Weerapana, Eranthie
1,3,5-三嗪衍生物在医药、材料、农化等领域有着广泛的应用。在生物领域，2,4,6-三取代1,3,5-三嗪的小分子文库已经为不同的蛋白质家族产生了选择性和有效的化学探针。 1,3,5-三嗪核心的结构对称性和易于功能化使其成为快速生成不同分子库的强大支架。已经开发了许多固相和溶液相合成路线来获得烷基/芳基氨基和氧取代的三嗪库。在这里，我们介绍了生成 2,4,6-三取代 1,3,5-三嗪的最新合成进展的一部分，并重点介绍了这些努力产生的生物活性化合物。
1,3,5-Triazine derivatives have widespread applications in the pharmaceutical, material, and agrochemical industries. In the biological arena, small-molecule libraries of 2,4,6-trisubstituted 1,3,5-triazines have yielded selective and potent chemical probes for diverse protein families. The structural symmetry and ease of functionalization of the 1,3,5-triazine core renders it a powerful scaffold for the rapid generation of diverse molecular libraries. Numerous synthetic routes, both solid-phase and solution-phase, have been developed to arrive at alkyl/aryl amino-and oxy-substituted triazine libraries. Here, we feature a subset of the recent synthetic advances towards generating 2,4,6-trisubstituted 1,3,5-triazines and highlight biologically active compounds that have resulted from these endeavors.