Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer.
Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer.
复制标题
DOI：
10.3390/medicines6010017
复制
发表时间：
2019-01-23
期刊：
影响因子：
--
通讯作者：
Townsend, Amanda R
中科院分区：
文献类型：
--
作者：
Nakhjavani, Maryam;Hardingham, Jennifer E;Townsend, Amanda R
乳腺癌仍然是最常见的癌症之一，也是全球癌症死亡的主要原因。癌症治疗的关键挑战是选择对患者毒性最小的最佳治疗剂。最近，从人参植物根部提取的草药化合物，特别是人参皂苷，引起了人们的注意。在各种研究中，人参皂苷的显著抗癌作用已被报道在不同的癌症中。本文就人参皂苷Rg3(Rg3)在体内外乳腺癌模型中的作用机制及其作为乳腺癌抗癌治疗的价值作一综述。
Breast cancer is still one of the most prevalent cancers and a leading cause of cancer death worldwide. The key challenge with cancer treatment is the choice of the best therapeutic agents with the least possible toxicities on the patient. Recently, attention has been drawn to herbal compounds, in particular ginsenosides, extracted from the root of the Ginseng plant. In various studies, significant anti-cancer properties of ginsenosides have been reported in different cancers. The mode of action of ginsenoside Rg3 (Rg3) in in vitro and in vivo breast cancer models and its value as an anti-cancer treatment for breast cancer will be reviewed.