Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats
Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats
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DOI：
10.1016/j.neulet.2007.12.019
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发表时间：
2008-02-27
影响因子：
2.5
通讯作者：
Bing, Guoying
中科院分区：
文献类型：
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作者：
Hunter, Randy L.;Choi, Dong-Young;Bing, Guoying
我们建立了炎症诱导的帕金森病模型，其中小胶质细胞活化导致黑质中的氧化应激、线粒体功能障碍和多巴胺能神经变性。吡格列酮是一种过氧化物酶体增殖物激活受体-γ（PPAR-gamma）激动剂，可以预防这些缺陷并保护多巴胺能神经元。为了继续探索吡格列酮在该模型中的作用，我们重点研究了PPAR-gamma、解偶联蛋白2（UCP 2）和mitoNEET的表达。我们报道了纹状体内脂多糖（LPS）增加纹状体PPAR-gamma、UCP 2和mitoNEET表达，吡格列酮减弱了这些LPS诱导的变化。出版社：Elsevier爱尔兰Ltd.
We created an inflammation-induced Parkinson's disease model, where microglia activation leads to oxidative stress, mitochondrial dysfunction, and dopaminergic neurodegeneration in the substantia nigra. Pioglitazone, an agonist of peroxisome proliferator activated receptor-gamma (PPAR-gamma), can prevent these deficits and protect dopaminergic neurons. To continue exploring the effects of pioglitazone in this model we focused on the expression of PPAR-gamma, uncoupling protein 2 (UCP2), and mitoNEET. We report that intrastriatal lipopolysaccharide, (LPS) increases striatal PPAR-gamma, UCP2, and mitoNEET expression, and pioglitazone attenuates these LPS-induced changes. Published by Elsevier Ireland Ltd.